Wine production generates millions of tons of grape pomace (the leftover skins, seeds, and stems) annually, which has traditionally been discarded as waste. This review shows that grape pomace is actually rich in valuable nutrients and compounds like polyphenols and fiber that provide significant health benefits including antioxidant, anti-inflammatory, and disease-fighting properties. By using grape pomace in functional foods, supplements, and cosmetics, the wine industry can reduce waste while creating sustainable products that promote human health.