therapeutic action: cholinergic system activation

The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics

This paper explores how the thalamus, a key brain structure controlling attention and perception, malfunctions in Parkinson’s disease and similar neurological conditions, causing hallucinations and delusions. Interestingly, these symptoms resemble the altered mental states produced by psychedelic drugs like LSD and psilocybin. By studying both conditions together, researchers found that a common mechanism called thalamocortical dysrhythmia disrupts how the brain filters information and processes reality, offering new insights for treating psychotic symptoms.

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