Researchers found that erinacine S, a compound from Lion’s Mane mushroom, can help kill colorectal cancer cells that have become resistant to chemotherapy drugs. The compound works by activating death pathways in cancer cells and modifying how genes are expressed. In mouse studies, erinacine S significantly reduced tumor growth compared to standard chemotherapy alone. This suggests Lion’s Mane mushroom derivatives could potentially be developed as a natural treatment option for patients with drug-resistant colorectal cancer.