therapeutic action: biofilm suppression

Fusarium Corneal Abscess: A Case Report

A 20-year-old healthy patient developed a serious fungal eye infection caused by Fusarium, a common soil fungus, despite having no typical risk factors like eye trauma or contact lens wear. The infection created an abscess (collection of pus) in the cornea and threatened the patient’s vision. Doctors used a combination of antifungal medications and eventually transplanted amniotic membrane tissue to prevent the cornea from rupturing, preserving the patient’s eyesight.

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Antifungal Potential of Streptomyces-Derived Metabolites Against Fluconazole-Resistant Oral Candida albicans: In vitro Evaluation and Mechanistic Insights

Researchers studied a type of soil bacteria called Streptomyces that produces natural compounds with strong antifungal properties. These compounds effectively killed drug-resistant Candida fungal infections that commonly affect cancer patients undergoing radiation therapy. The bacterial extract worked by damaging fungal cell membranes and blocking biofilm formation, which are protective structures the fungus uses to survive. While the results are promising for treating stubborn fungal infections, more research is needed to ensure safety for human patients.

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