therapeutic action: antifungal treatment

Antifungal Policy and Practice Across Five Countries: A Qualitative Review

This study examines how well five different countries handle invasive fungal infections through their healthcare policies and systems. Researchers found that while these infections affect millions of people globally, most countries lack comprehensive policies to diagnose, treat, and manage them effectively. Major issues include inadequate healthcare provider training, limited access to rapid diagnostic tests, and insufficient antifungal medications in some regions. The study recommends that countries develop better national strategies for preventing, diagnosing, and treating these serious infections.

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Awareness and perception of invasive fungal diseases among the Nigerian population

This study found that very few Nigerians (only about 19%) are aware of serious fungal infections like candidiasis and aspergillosis, and most people don’t understand how dangerous these diseases can be. The researchers surveyed over 1,200 people and discovered that people with more education and higher incomes were more likely to know about these infections. The findings suggest that Nigeria urgently needs public health campaigns and education programs to help people recognize fungal diseases early so they can get proper treatment.

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China’s innovative national plan to combat fungal diseases and antifungal resistance

China has created a comprehensive national system to fight fungal infections and drug resistance. The system monitors fungal diseases across hundreds of hospitals throughout the country to track which infections are most common and which antifungal medicines are becoming less effective. Early findings show that many hospitals lack proper facilities for testing fungal infections, and some fungi are developing resistance to commonly used antifungal drugs, particularly fluconazole.

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Inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in susceptible pediatric patients: a case series

This case series describes three children in Iran who developed serious lung infections caused by a fungal organism called Aspergillus flavus. Tragically, two of the three children died because their infections were diagnosed too late and they did not receive appropriate antifungal medications. The study emphasizes that children with weakened immune systems need quick diagnosis and proper antifungal treatment to survive these dangerous fungal infections.

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Assessing Diagnostic Capabilities and Treatment Accessibility for Invasive Fungal Infections in the Balkan Region

Researchers surveyed medical centers across 12 Balkan countries to understand how well-equipped they are to diagnose and treat serious fungal infections. They found that while most centers have basic laboratory tools like microscopes and cultures, advanced molecular tests for identifying fungal species are less common. Antifungal medications like triazoles are widely available, but other important treatment options are harder to find in the region.

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A case of refractory onychomycosis caused by Kloeckera apiculata: Successful treatment with itraconazole

A 32-year-old man had a stubborn fungal nail infection caused by an extremely rare yeast called Kloeckera apiculata that didn’t respond to three different antifungal treatments over several years. After being identified through specialized laboratory testing including genetic sequencing, the infection was successfully cured with a 3-month course of the oral antifungal medication itraconazole. This case is notable because it is only the fourth known case of this rare fungal infection in humans and the first one to achieve complete cure with itraconazole treatment.

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China’s innovative national plan to combat fungal diseases and antifungal resistance

China has launched an ambitious national program to combat fungal diseases through a network of 868 hospitals across the country. Studies found that fungal infections are more common than previously thought, with concerning rates of drug resistance. The country is implementing surveillance systems, training healthcare workers, and carefully managing antifungal drug use to prevent further resistance development while improving patient outcomes.

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Should all hospitalised patients colonised with Candida auris be considered for isolation?

Candida auris is a dangerous yeast found in hospitals that can spread quickly between patients and is very difficult to treat. Healthcare experts in the Netherlands have decided that all hospital patients carrying this fungus should be isolated in single rooms, even if their strain is susceptible to antifungal drugs, because the infection can develop resistance quickly and cause serious illness. This strict isolation approach helps prevent outbreaks and protects vulnerable patients from developing life-threatening blood infections.

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Fungal infections in burn patients: The rise of Fusarium as the most prevalent in a burn center in Mexico City

Burn patients are at high risk for serious fungal infections that can cause death. This study from a Mexican burn hospital found that a fungus called Fusarium was the most common cause of these infections, affecting over half of patients with fungal infections. This finding differs from other parts of the world where Aspergillus is usually most common, suggesting that Mexican burn patients face unique fungal threats that doctors should watch for carefully.

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Fungi under fire: diagnostic capacities and antifungal availability in Peruvian healthcare facilities

This study examined how well Peruvian hospitals can diagnose and treat serious fungal infections across the country. Researchers surveyed 54 healthcare centers and found that while basic fungal tests are available everywhere, advanced diagnostic tools and certain antifungal medications are mostly limited to the capital city of Lima. The research identifies major gaps in care that need to be addressed to help more patients survive these serious infections.

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