therapeutic action: Antifungal treatment with fluconazole

The emerging fungal pathogen Cryptococcus gattii: Epidemiology, pathogenesis, immunomodulatory attributes, and drug susceptibility

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Cryptococcus gattii is a dangerous fungal infection that can affect even healthy people, unlike most fungal infections that target those with weak immune systems. The fungus uses clever tricks to hide from the immune system, including creating protective capsules and producing melanin. Current antifungal drugs like fluconazole are becoming less effective as the fungus develops resistance, making this an urgent public health concern that requires better treatments and early detection.

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Candida blankii: The Difficult Capture of a Fungus With Pathogenic Potential

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Candida blankii is a rare fungal pathogen that is increasingly being found in hospital patients’ bloodstreams and respiratory tracts. The organism is difficult to identify using standard laboratory tests, which can delay diagnosis and treatment. This case report describes two adult patients with C. blankii infections and highlights the challenges in identifying this emerging pathogen and its resistance to common antifungal medications.

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Identification of fungal agents isolated from burn lesions using mycological and molecular methods in patients admitted to Velayat burn hospital in Rasht city during 2022–2023

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Researchers studied fungal infections in burn patients at a hospital in Iran and found that non-albicans Candida fungi, particularly a species called Candida parapsilosis, were the most common culprits. Using laboratory cultures and genetic testing, they identified 101 fungal infections out of 380 burn patients. Understanding which fungi cause these infections is important for doctors to choose the right treatment and improve patient outcomes.

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The refractory nailbed ulceration caused by Candida parapsilosis after nail extraction

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An 82-year-old woman developed a stubborn ulcer on her toenail bed after having the nail surgically removed to treat an infected nail fold. Testing revealed the ulcer was caused by a yeast called Candida parapsilosis, which typically causes infections after physical trauma or injury to the skin. Treatment with an antifungal medication called fluconazole successfully healed the ulcer over three months. This is the first reported case of this specific type of infection following nail removal and highlights the importance of properly identifying the cause of chronic nail infections.

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