Antifungal therapy – Page 2

Musculoskeletal Manifestations of Disseminated Fungal Infections

mycolabadmin

Fungal infections can spread to bones and joints, causing serious complications especially in people with weakened immune systems. These infections are tricky to diagnose because their symptoms are similar to bacterial infections or other diseases. Treatment typically involves antifungal medications and sometimes surgery to remove infected tissue. Early detection and aggressive treatment are crucial for better patient outcomes.

Black mold in the bag room: First case of Arthrocladium tropicale peritonitis in a peritoneal dialysis patient

mycolabadmin

A peritoneal dialysis patient contracted a rare fungal infection caused by Arthrocladium tropicale, a mold found in damp environments and associated with ant nests. The infection was diagnosed through microscopy and genetic testing, revealing resistance to one antifungal drug but susceptibility to amphotericin B. Treatment with this antibiotic and removal of the dialysis catheter led to full recovery, highlighting the importance of keeping medical equipment storage areas dry and pest-free.

Frequency, Interval, and Patient Factors Associated With Recurrence of Disseminated Cutaneous Coccidioidomycosis

mycolabadmin

This study looked at how often a serious fungal skin infection called coccidioidomycosis comes back after treatment. Researchers found that about 25% of patients experienced at least one recurrence after stopping antifungal medications, with the average time before it returned being 14 months. Some patients had multiple recurrences, and most of the time the infection returned to the same location on the body.

Enhancing antifungal stewardship: The educational and healthcare benefits of involving pharmacy students in audits

mycolabadmin

This study examined how pharmacy students could help improve the use of fluconazole, a common antifungal medication, in hospitals. Researchers found that nearly one-third of fluconazole prescriptions were not being used appropriately. By having pharmacy students participate in reviewing prescriptions under expert supervision, hospitals could better identify problems and educate future pharmacists, while the students gained valuable real-world experience in patient care.

Estimated burden of serious mycoses in Poland

mycolabadmin

This study reveals that Poland has a significant but underreported problem with serious fungal infections affecting thousands of people annually. The most common fungal infections are yeast infections like candidosis, while mold infections like aspergillosis are the most serious in immunocompromised patients. The research shows that current reporting systems severely underestimate the true burden of these infections, highlighting the need for better surveillance and diagnostic practices.

Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing

mycolabadmin

A patient with a serious fungal infection of the sinuses caused by Rhizopus arrhizus received the antifungal drug isavuconazole. However, blood tests showed the drug was building up to dangerously high levels in her body. Genetic testing revealed she had a mutation that made her body unable to break down the drug normally. The doctors had to give her much smaller and less frequent doses while carefully monitoring her drug levels to keep her safe.

Data analysis of patients with positive mould or dimorphic fungal cultures from sterile sites

mycolabadmin

This study examined 48 patients with serious mould and fungal infections at a South African hospital between 2014-2017. Most infections occurred in people with weak immune systems, especially those with HIV. The most common fungal type was Aspergillus. Even with appropriate antifungal medicines, one-quarter of patients died, highlighting how serious these infections can be.

Evaluation of Clinical, Microbiological Profiles and Management Patterns with Outcomes of Patients with Fungal Isolates in An Intensive Care Unit of A Tertiary Care Center: A Prospective Observational Study

mycolabadmin

This study examined fungal infections in intensive care unit patients at a major hospital in India. Researchers found that diabetes was the most common risk factor, and most infections were caused by Candida species found in urine samples. Many fungal isolates were resistant to common antifungal drugs like fluconazole, suggesting doctors need to be more careful about which medications they use to treat these infections.

Invasive Cutaneous Mucormycosis in a Patient With Chronic Lymphocytic Leukemia on Obinutuzumab, Idelalisib, and Bruton Tyrosine Kinase Degrader: A Case Report

mycolabadmin

A 74-year-old man with blood cancer developed a serious fungal skin infection caused by Mucorales while taking multiple targeted cancer drugs. The infection appeared as a darkening ulcer on his ankle that rapidly worsened. Doctors diagnosed it using a skin biopsy showing characteristic fungal structures, though standard fungal tests came back negative. The patient required amputation of his leg below the knee to remove all the infected tissue, along with antifungal medications, and ultimately recovered.

Knowledge framework and emerging trends of invasive pulmonary fungal infection: A bibliometric analysis (2003–2023)

mycolabadmin

This study examined 20 years of scientific research on invasive lung fungal infections using bibliometric analysis. The research found that the United States leads in fungal infection research, with emerging focus areas including COVID-19-associated fungal infections and new diagnostic methods like metagenomic sequencing. The findings show that diagnosis remains challenging and requires improved detection methods, while treatment typically involves antifungal medications like voriconazole and amphotericin-B.

therapeutic action: Antifungal therapy