therapeutic action: Antifungal prophylaxis

Cracks in the Curriculum: The Hidden Deficiencies in Fungal Disease Coverage in Medical Books

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Medical textbooks used to train doctors contain significant gaps in their coverage of fungal infections, which cause millions of deaths annually. While infectious disease textbooks provide better information than general internal medicine textbooks, all of them fall short in covering important topics like diagnosis methods and prevention strategies. The study found that doctors and students relying solely on these textbooks may not have adequate knowledge to properly diagnose and treat fungal infections, which could impact patient care outcomes.

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Inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in susceptible pediatric patients: a case series

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This case series describes three children in Iran who developed serious lung infections caused by a fungal organism called Aspergillus flavus. Tragically, two of the three children died because their infections were diagnosed too late and they did not receive appropriate antifungal medications. The study emphasizes that children with weakened immune systems need quick diagnosis and proper antifungal treatment to survive these dangerous fungal infections.

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Liposomal amphotericin B prophylaxis in paediatrics: a systematic review

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This study reviews how a fungal medication called liposomal amphotericin B is used to prevent serious fungal infections in children with weakened immune systems, particularly those with blood cancers or who have had bone marrow transplants. The researchers found that this medicine prevents infections in about 93% of children, though it does cause side effects like low potassium levels in about 23% of patients. However, the study shows that current use of this medicine is quite varied and more high-quality research is needed to determine the best dosing approach.

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Enhancing antifungal stewardship: The educational and healthcare benefits of involving pharmacy students in audits

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Researchers studied how involving pharmacy students in reviewing fluconazole (an antifungal medication) prescriptions could help hospitals improve their antifungal medication use and provide valuable training. Out of 145 prescriptions audited, about two-thirds were appropriate while one-third had issues like unnecessary use or drug interactions. Both the students and hospitals benefited significantly, with students gaining practical clinical experience while hospitals identified prescribing problems that could be improved.

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Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review

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This study examines rare but serious fungal infections in patients with chronic granulomatous disease, a genetic immune disorder. Researchers analyzed 122 cases of non-Aspergillus fungal infections from French hospitals and published literature, finding that these infections often occur despite preventive antifungal medications and are challenging to diagnose. The infections were found in the lungs most commonly but could spread to bones, brain, and other organs, with treatments including antifungal drugs, surgery, and in some cases bone marrow transplants.

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Incidence And Risk Factors for Invasive Fungal Infections in Pre-Transplant and Transplant-Ineligible Multiple Myeloma in the U.S.: A Claims Analysis (2017-2021)

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This study examined fungal infections in patients with multiple myeloma who were not eligible for or preparing for stem cell transplants. Researchers found that 6% of these patients developed invasive fungal infections, with yeast infections being the most common type. The risk of these infections was significantly higher in patients taking dexamethasone (a steroid) or those with low white blood cell counts and those receiving multiple cancer therapies.

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