antifungal activity – Page 9

Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy

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This report describes two patients who developed rare fungal eye infections caused by Curvularia geniculata after eye injuries. Both patients were successfully treated with antifungal eye drops, particularly natamycin. Molecular testing confirmed the specific fungus causing the infection. Both patients recovered well with excellent vision restoration, demonstrating that proper diagnosis and targeted antifungal treatment can effectively manage this rare condition.

Inhibition of Fusarium oxysporum growth in banana by silver nanoparticles: In vitro and in vivo assays

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Researchers tested silver nanoparticles as a potential cure for Fusarium wilt, a serious fungal disease that damages banana crops worldwide. Using laboratory tests and greenhouse experiments with banana plants, they found that silver nanoparticles effectively killed the fungus and reduced disease symptoms by about 68% when applied to plant roots. The study shows that this nanotechnology approach could offer a new way to protect banana plantations from this devastating disease.

Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis

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Researchers used heavy-ion radiation to create improved strains of a fungus that produces a precursor to micafungin, an important antifungal drug. The improved strains produced over 3.5 times more of the desired compound than the original strain. By analyzing the genetic changes in these improved strains, the scientists identified which genes were most important for boosting production, helping guide future improvements in manufacturing this life-saving medicine.

Sunlight-sensitive carbon dots for plant immunity priming and pathogen defence

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Scientists developed special tiny carbon particles that respond to sunlight by producing molecules that strengthen plant defenses against fungi. When sprayed on plants like tomato and tobacco, these particles trigger the plant’s natural immune system, reducing fungal diseases by 12-44% without harming the plant. At higher concentrations with continuous sunlight, the particles can directly kill fungal pathogens. This eco-friendly approach offers a sustainable alternative to chemical fungicides while maintaining crop yields.

Complete genome analysis and antimicrobial mechanism of Bacillus velezensis GX0002980 reveals its biocontrol potential against mango anthracnose disease

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Researchers found a beneficial bacterium called Bacillus velezensis that can effectively fight the fungus causing brown spots on mangoes. The bacterium produces natural antibiotic compounds that kill the disease-causing fungus and can be sprayed on mangoes to keep them fresh longer during storage. This discovery offers a safer, eco-friendly alternative to harsh chemical fungicides for protecting the mango harvest.

Chemical profile and bioactivity of essential oils from five Turkish thyme species against white mold fungal disease agent Sclerotinia sclerotiorum

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Researchers tested essential oils from five different thyme species grown in Turkey against a common plant fungus that causes white mold disease. They found that oils rich in carvacrol, particularly from Thymbra spicata and Satureja cilicica, were very effective at stopping fungal growth. These natural oils could be used as environmentally friendly alternatives to chemical pesticides in farming.

Transcriptomics Insights into Targeting CK2 Complex in Cryptococcus neoformans: Implications for Large-Scale Antifungal Virtual Screening

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Scientists studied how a fungus called Cryptococcus neoformans causes serious brain infections and found that disabling a specific protein complex (CK2) could be an effective treatment strategy. Using computer analysis of genetic data, they identified three existing drugs—amphotericin B, idarubicin, and candicidin—that could potentially target and kill this dangerous fungus. This research provides a foundation for developing better treatments for cryptococcal meningitis, a life-threatening infection that kills hundreds of thousands of people annually, especially those with weakened immune systems.

Clinical aspects and recent advances in fungal diseases impacting human health

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Fungal infections are increasingly common health threats affecting over a billion people worldwide, ranging from minor allergies to serious life-threatening infections. The biggest problems are that fungi are becoming resistant to current medications, diagnosis can be difficult and slow, and treatment options are limited. Recent developments include new antifungal drugs like ibrexafungerp and rezafungin that work differently from older medications, offering hope for treating resistant infections. Better awareness among doctors and patients, faster diagnostic methods, and responsible use of antifungals are essential to combat this growing public health challenge.

Study on the inhibitory mechanism of fig leaf extract against postharvest Fusarium in melon

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Researchers discovered that fig leaves contain natural compounds that can prevent fruit rot caused by Fusarium fungus in melons. When applied to infected melons, the fig leaf extract kills the fungus by damaging its cell membranes and overwhelming it with harmful molecules called reactive oxygen species. This natural treatment could replace chemical fungicides that harm the environment and leave residues on food, offering a safer way to preserve melons during transport and storage.

New Strategies to Combat Human Fungal Infections

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Fungal infections are becoming a major global health threat, causing millions of deaths annually. This research collection presents new and improved ways to treat these infections, including natural compounds like chitosan, beneficial bacteria, new drug combinations, and tests to better understand which treatments work best. The papers showcase innovative approaches beyond traditional antifungal medications to help combat resistant infections.

therapeutic action: antifungal activity