antifungal activity – Page 6

Synergistic potential and apoptosis induction of Bunium persicum essential oil and its pure components, cuminaldehyde and γ-terpinene, in combination with fluconazole on Candida albicans isolates: in vitro and in silico evaluation

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Researchers tested a spice-derived essential oil called Bunium persicum and two of its active compounds to see if they could work better with the antifungal drug fluconazole against drug-resistant yeast infections. They found that one component called cuminaldehyde was particularly effective and worked synergistically with fluconazole, meaning the combination was more powerful than either treatment alone. These natural compounds could potentially help treat fungal infections that no longer respond to standard medications, offering a promising approach using plant-based remedies alongside conventional drugs.

Microminutinin, a Fused Bis-Furan Coumarin from Murraya euchrestifolia, Exhibits Strong Broad-Spectrum Antifungal Activity by Disrupting Cell Membranes and Walls

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Researchers discovered a natural compound called microminutinin from a plant used in traditional medicine. This compound shows strong ability to kill various fungal pathogens that damage crops, particularly tea plants. The compound works by breaking down the protective structures of fungal cells, making it a promising candidate for developing safer, plant-based fungicides for agriculture.

Antifungal mechanism of ketone volatile organic compounds against Pseudogymnoascus destructans

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Researchers discovered that two ketone compounds, 2-undecanone and 2-nonanone, effectively kill Pseudogymnoascus destructans, the fungus that causes white-nose syndrome in bats. Using advanced genetic analysis, they found these ketones work by damaging the fungus’s cell structure, disrupting its energy production, and causing DNA damage. This research provides a foundation for developing new fumigant treatments to protect bat populations from this devastating fungal disease.

Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis

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An 18-year-old cancer patient undergoing chemotherapy developed a serious infection with Fusarium, a mold that spread throughout his body including to his eyes, causing vision problems. Doctors treated him with a combination of antifungal medications given both systemically and directly injected into his eyes. Although the infection was controlled and his life was saved, he lost most of his vision in both eyes but was able to keep them rather than requiring removal.

Isolation and Identification of Endophytic Bacterium B5 from Mentha haplocalyx Briq. and Its Biocontrol Mechanisms Against Alternaria alternata-Induced Tobacco Brown Spot

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Scientists discovered a beneficial bacterium called Bacillus velezensis in mint plants that can fight tobacco brown spot disease caused by a fungus. This bacterium works by producing natural antifungal compounds and enzymes that damage the fungus, and it helps boost the plant’s own defense systems. In greenhouse tests, this bacterial treatment was as effective as commercial chemical fungicides, offering farmers a safer, more environmentally friendly option for protecting their tobacco crops.

Prevalence of toxigenic fungi and mycotoxins in Arabic coffee (Coffea arabica): Protective role of traditional coffee roasting, brewing and bacterial volatiles

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This study examined toxin-producing fungi and harmful mycotoxins found in coffee sold in Qatar markets. Researchers tested whether traditional coffee roasting and brewing methods reduce these harmful compounds, and also tested a beneficial bacterium that produces antifungal compounds. They found that higher roasting temperatures and brewing significantly reduced the dangerous toxins, and the bacterial volatiles completely stopped fungal growth on coffee beans, offering a natural alternative to chemical fungicides.

Bacterial–Fungal Interactions: Mutualism, Antagonism, and Competition

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Bacteria and fungi in animal bodies interact in three main ways: they help each other (mutualism), fight each other (antagonism), or compete for resources. These interactions happen in the gut, rumen, and skin of animals. Understanding how to balance these relationships can help create better probiotics and natural alternatives to antibiotics for treating infections and improving animal health.

Fusarium Corneal Abscess: A Case Report

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A 20-year-old healthy patient developed a serious fungal eye infection caused by Fusarium, a common soil fungus, despite having no typical risk factors like eye trauma or contact lens wear. The infection created an abscess (collection of pus) in the cornea and threatened the patient’s vision. Doctors used a combination of antifungal medications and eventually transplanted amniotic membrane tissue to prevent the cornea from rupturing, preserving the patient’s eyesight.

Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius

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Researchers studied how a chemical called dimethyl fumarate stops the growth of a dangerous fungus (Aspergillus carbonarius) that damages grapes and produces a toxin called ochratoxin A. By analyzing which genes were turned on and off when the fungus was exposed to this chemical, they found that it works by damaging the fungus’s cell walls and disrupting its normal development. This discovery could help protect fruit crops and food safety by providing a natural and non-toxic way to prevent mold growth.

Morphological, molecular, and biological characterization of bulb rot pathogens in stored Lanzhou lily and the in vitro antifungal efficacy of three plant essential oils

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Lanzhou lily is a valuable medicinal and food plant that loses 20-25% of its crop annually due to fungal rot during storage. Researchers identified the main culprit as a fungus called Fusarium oxysporum and found that natural essential oils from cinnamon, tea tree, and angelica plants can effectively inhibit this fungus’s growth. Cinnamon essential oil proved most effective and could serve as a natural alternative to chemical fungicides for protecting stored lily bulbs.

therapeutic action: antifungal activity