therapeutic action: antifungal activity

The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release

Researchers discovered that a small peptide derived from a bacterium called EntV can fight Candida fungal infections by targeting specialized vesicles (tiny sacs) that fungi use to spread infections. Unlike traditional antifungal drugs that kill fungi, EntV works by blocking the release of these vesicles, reducing the fungus’s ability to infect and form protective biofilms. This new approach could lead to treatments that work against drug-resistant fungi without the toxicity issues of current antifungals.

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Discovery of novel targets for important human and plant fungal pathogens via an automated computational pipeline HitList

Scientists developed a computer program called HitList that searches through fungal genes to find new targets for antifungal medicines. The program identifies proteins that are unique to harmful fungi and missing from humans and plants, making them ideal drug targets. The study found several promising new protein targets that could lead to development of more effective antifungal drugs to treat both human fungal infections and crop diseases caused by fungi.

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The role of Npt1 in regulating antifungal protein activity in filamentous fungi

Researchers discovered how antifungal proteins work against a dangerous fungus (Aspergillus flavus) that damages crops and produces toxins. They found that these proteins break down the fungal cell wall and then interact with an internal fungal protein called Ntp1. By understanding exactly which part of Ntp1 the antifungal proteins bind to, scientists can now develop better treatments to protect food crops from fungal diseases.

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