antifungal activity – Page 37

Identification and growth-promoting effect of Paecilomyces lilacinus a biocontrol fungi for walnut rot disease

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Researchers identified a beneficial fungus called Paecilomyces lilacinus that can fight walnut rot disease, which damages walnut crops especially in China’s Xinjiang region. This fungus is more environmentally friendly than chemical fungicides and actually boosts walnut plant growth, increasing seedling height and root development significantly. The study shows it could replace harmful chemical treatments while improving overall plant health.

Efficacy of SCY-247, a Second-generation Triterpenoid Antifungal, in Three Murine Models of Invasive Fungal Infections

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Researchers tested a new antifungal drug called SCY-247 in mice to treat serious fungal infections. The drug was given orally and showed strong effectiveness against common fungal infections caused by Candida and Rhizopus species, including strains resistant to current treatments. Higher doses of the drug produced better results, and the drug effectively concentrated in the organs most affected by fungal infections.

Development of a granular bioformulation of Achromobacter xylosoxidans AX77 16S for sustainable onion white rot management and growth enhancement

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Scientists discovered a beneficial bacterium living inside onion seeds that can fight a serious fungal disease called white rot and help seeds grow better. They turned this bacterium into an easy-to-use granular product that lasts up to a year, offering farmers an environmentally friendly alternative to chemical fungicides. The product not only prevents the fungal disease but also improves seed germination and plant growth, making it a promising sustainable solution for onion farming.

Engineered biosynthesis and characterization of disaccharide-pimaricin

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Scientists successfully created a genetically engineered bacterium that produces a safer version of an antifungal drug called pimaricin. The new version, called disaccharide-pimaricin, dissolves much better in water and causes significantly less damage to human blood cells, making it a much safer option for treating fungal infections. Although it’s slightly less effective at killing fungi, the improvement in safety and solubility makes it a promising candidate for treating eye infections and other fungal diseases.

Characterisation of Plant Growth-Promoting Endophytic Bacteria from Sugarcane and Their Antagonistic Activity against Fusarium moniliforme

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Researchers isolated and identified fourteen types of beneficial bacteria living inside sugarcane plants that can fight against a harmful fungus called Fusarium moniliforme, which damages both sugarcane and rice crops. These bacteria not only kill the fungus but also help plants grow better by producing growth-promoting compounds. When used as a seed treatment, the bacteria reduced fungal infection in rice seedlings by 80%, offering a natural alternative to chemical fungicides.

Identification of an antifungal lipopeptide from Bacillus amyloliquefaciens HAU3 inhibiting the growth of Fusarium graminearum using preparative chromatography and 2D-NMR

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Researchers identified a soil bacterium called Bacillus amyloliquefaciens HAU3 that naturally produces fengycin, a powerful antifungal compound. This compound can kill disease-causing fungi like Fusarium graminearum that contaminate animal feed and produce harmful toxins. The bacteria also breaks down dangerous toxins called zearalenone, making it a potential natural solution for protecting livestock feed from fungal contamination.

A case of corneal infection with Clonostachys rosea

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A 53-year-old patient developed a corneal infection caused by a fungus called Clonostachys rosea, likely from an eye injury. This is the first reported case of this particular fungus infecting the cornea. The infection was successfully treated with antifungal eye drops and oral medications, with the ulcer healing into a scar within one month.

Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23

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Researchers discovered two new antimicrobial compounds called pyrrolomycins from a bacterium found in termite guts using genome analysis and advanced chemistry techniques. These compounds are modified versions of known antimicrobial molecules, featuring halogenated structures. Interestingly, the bacteria appears to protect itself from its own toxic compounds through chemical modifications, a strategy that researchers believe could inform the design of new antibiotics to combat drug-resistant bacteria.

Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review

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A 50-year-old woman with advanced lung cancer developed a rare fungal eye infection caused by Cryptococcus neoformans, resulting in blurred vision. Doctors diagnosed this through eye surgery and fluid analysis, then treated her with strong antifungal medications both injected into the eye and given systemically. After 10 months of treatment, her vision significantly improved, showing that early detection and aggressive antifungal therapy are critical for preventing blindness from this rare infection.

Antifungal potential of copper oxide nanoparticles against Microsporum canis isolates in canine and feline dermatophytosis

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Researchers tested tiny copper oxide particles created using plant extracts against a fungus that causes ringworm in dogs and cats. These nanoparticles successfully killed the fungus in laboratory tests, with effectiveness at concentrations ranging from 500-2,000 parts per million. While slightly less effective than current medications, the nanoparticles showed promise as an alternative treatment, especially important as the fungus becomes resistant to traditional drugs.

therapeutic action: antifungal activity