antifungal activity – Page 36

Rhinocerebral Mucormycosis in a Patient With Diabetes: A Rare but Critical Infection in the United Arab Emirates

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A middle-aged man with undiagnosed diabetes developed a serious fungal infection called mucormycosis that affected his sinuses, eyes, and brain. He presented with flu-like symptoms and facial weakness, and blood tests showed dangerously high blood sugar and acid levels (diabetic ketoacidosis). Doctors treated him with multiple rounds of antifungal medications, several surgeries, and innovative injections directly into and around his eyes and spinal cord, resulting in his successful recovery and discharge.

Polyherbal nanoformulation: a potent antifungal agent on fungal pathogens of Coffea arabica

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Researchers developed an eco-friendly nano-formulation from Triphala to fight fungal diseases that harm coffee plants. The treatment effectively stopped the growth of five different harmful fungi that infect coffee leaves. This green nanotechnology approach offers farmers a safer, environmentally friendly alternative to chemical fungicides that can pollute the environment and harm human health.

Utility of MALDI-ToF MS for Recognition and Antifungal Susceptibility of Nannizzia, an Underestimated Group of Dermatophytes

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Nannizzia species are soil-dwelling fungi that increasingly cause stubborn skin, nail, and hair infections in humans and animals. This study tested two laboratory methods for identifying these fungi and measured their sensitivity to eight antifungal drugs. The faster liquid-based method was slightly more accurate (67%) than the traditional culture method (62%), though neither method could identify six very rare species. Terbinafine emerged as the most effective antifungal treatment in laboratory tests.

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Scientists tested five synthetic compounds called naphthoquinones to see if they could fight a serious fungal infection called cryptococcosis. They found that one compound called 2-MNQ worked well against the fungus and was even more effective when combined with a standard antifungal drug (amphotericin B). The combination was strong enough to potentially allow lower doses of the existing drug, which could reduce side effects while improving treatment outcomes.

Efficacy and safety of isavuconazole for invasive fungal infections: A systematic review and meta-analysis of randomized controlled trials

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Isavuconazole is an antifungal medication used to treat serious fungal infections in people with weakened immune systems. This study reviewed and analyzed three clinical trials to compare how well isavuconazole works compared to other antifungal drugs. The results showed that isavuconazole is just as effective as other antifungals but has fewer side effects, particularly fewer problems with liver health and drug-related adverse events. This makes isavuconazole a good alternative choice for patients who cannot use other antifungal medications or who are at risk of liver damage.

Combination of Q-switched 1,064 and 532 nm Nd: YAG laser in the treatment of toenail onychomycosis: a pilot study

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This study tested a dual-wavelength laser treatment for toenail fungal infections (onychomycosis) in 15 patients. The laser therapy successfully cured about one-third of patients with mild infections, but was less effective for severe cases. The treatment was safe and well-tolerated, though patients experienced moderate pain during sessions.

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Scientists are exploring nano-graphene oxide, a microscopic material made from graphene, as a new treatment for serious lung fungal infections. These tiny particles can kill fungal cells through multiple mechanisms and deliver antifungal drugs directly to infection sites while reducing harmful side effects. Researchers found that graphene oxide can be combined with existing antifungal medications to make them work better and even help overcome drug-resistant fungal infections.

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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This study examined fungal infections in HIV-positive patients’ mouths at an Indonesian hospital. Researchers identified which Candida species caused the infections and tested how well common antifungal medications worked against them. They found that while a specific antifungal drug (fluconazole) was effective in most cases, some infections showed resistance, suggesting the need for careful monitoring and personalized treatment approaches.

Application and Mechanism of Action of Carvacrol Against Aspergillus niger Causing Postharvest Rot of Garlic Scapes (Allium sativum L.)

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Garlic scapes, the tender flower stalks of garlic plants, often rot during storage due to fungal infections. Researchers discovered that carvacrol, a natural compound found in herbs like thyme and oregano, effectively kills the fungi responsible for this spoilage. By damaging the fungal cell walls, carvacrol can help preserve fresh garlic scapes longer without synthetic chemicals, making it a promising natural food preservative for grocery stores and consumers.

Identification, characterization, antimicrobial activity and biocontrol potential of four endophytic fungi isolated from Amazonian plants

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Scientists isolated four types of fungi living inside the leaves of medicinal plants from the Amazon region of Bolivia. These fungi produce natural compounds that kill harmful bacteria and fungi that damage potato crops. The findings show promise for developing natural alternatives to synthetic pesticides and antibiotics for agricultural and medical applications.

therapeutic action: antifungal activity