antifungal activity – Page 33

Superficial Fungal Infections in Children—What Do We Know?

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Fungal infections of the skin, hair, and nails are increasingly common in children worldwide, especially in warm, humid climates and in crowded living conditions. These infections are caused by germs that live on the skin and can spread through contact with infected people or animals. Children are particularly vulnerable due to their developing immune systems, but most infections are treatable with topical creams or oral medications, with terbinafine being the most effective option currently available.

Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes

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Researchers discovered that amphotericin B, a natural compound produced by soil bacteria, effectively prevents gray mold disease on table grapes. The compound works by directly damaging the fungus’s cell membranes and also boosts the grape’s own defense mechanisms. This natural solution could replace harmful synthetic fungicides while extending the shelf life of grapes during storage and transport.

Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi

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Termite colonies farm a fungus called Termitomyces for food in an ancient partnership. Scientists discovered that the mushrooms produced by this fungus release distinctive chemical signals, particularly a compound called drimenol. By isolating and synthesizing these compounds, researchers found they have antimicrobial properties and may play a role in communicating between termites and their fungal crop or protecting mushrooms from infection.

Impact of Various Essential Oils on the Development of Pathogens of the Fusarium Genus and on Health and Germination Parameters of Winter Wheat and Maize

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Researchers tested four plant-based essential oils as natural alternatives to chemical fungicides for protecting wheat and maize seeds from harmful Fusarium fungi. Thyme oil proved most effective at preventing fungal infections and seedling disease, performing as well as synthetic fungicides. However, thyme oil at higher doses harmed seed germination and plant growth, suggesting careful dose selection is needed for practical use. The findings indicate essential oils could replace chemical pesticides while maintaining crop safety, though different oils must be tested for various crops.

Biocontrol Potential of a Mango-Derived Weissella paramesenteroides and Its Application in Managing Strawberry Postharvest Disease

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Researchers discovered a beneficial bacterium called Weissella paramesenteroides that naturally lives on mango fruit and can protect strawberries from fungal diseases during storage. The bacterium works by releasing special chemicals in the air called volatile organic compounds that prevent mold growth without direct contact. This provides a natural, food-safe alternative to synthetic fungicides for keeping fresh fruit fresher longer.

Antifungal Activity of Genistein Against Phytopathogenic Fungi Valsa mali Through ROS-Mediated Lipid Peroxidation

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Scientists discovered that genistein, a natural compound found in soybeans and other legumes, can effectively kill the fungus that causes apple tree canker disease. The compound works by creating harmful reactive oxygen species that damage the fungus’s cell membranes and disrupt its normal cellular functions. This research suggests genistein could be developed as a safe, natural alternative to chemical fungicides for protecting apple crops.

Antifungal activity of zinc oxide nanoparticles (ZnO NPs) on Fusarium equiseti phytopathogen isolated from tomato plant in Nepal

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Researchers in Nepal isolated a fungus called Fusarium equiseti that damages tomato plants and created tiny zinc oxide particles from tea leaves to fight it. These nanoparticles successfully stopped the fungus from growing, reducing its growth by up to 85%. This discovery offers farmers an environmentally friendly alternative to chemical fungicides that harm the environment and create resistant fungi.

Identification of an antifungal lipopeptide from Bacillus amyloliquefaciens HAU3 inhibiting the growth of Fusarium graminearum using preparative chromatography and 2D-NMR

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Scientists discovered a beneficial soil bacterium called Bacillus amyloliquefaciens that produces a natural antifungal compound called fengycin, which effectively kills dangerous mold (Fusarium graminearum) that contaminates animal feed. This bacterium can be used as a biological control agent to prevent fungal growth and reduce harmful mycotoxins in livestock feed, offering a safer and more environmentally friendly alternative to chemical fungicides. The study shows the bacterium’s compounds damage fungal cell membranes and generate harmful stress molecules that kill the fungus.

Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability

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Researchers tested a new antifungal drug called olorofim against 253 different Fusarium fungi that infect humans. Fusarium is particularly dangerous for people with weakened immune systems and resists most common antifungals. The study found that olorofim works, but its effectiveness varies significantly depending on which type of Fusarium is present. While these lab results are promising, additional testing in animal models is needed before it can be used clinically.

Superhydrophobic Fatty Acid-Based Spray Coatings with Dual-Mode Antifungal Activity

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Researchers developed special water-repellent coatings made from natural fatty acids that can prevent fungal infections. These coatings work in two ways: they physically prevent fungi from sticking to surfaces through their bumpy structure, and they chemically kill fungi that do land on them. The coatings can be easily sprayed on like paint and offer an environmentally friendly alternative to traditional antifungal treatments that are becoming less effective.

therapeutic action: antifungal activity