antifungal activity – Page 32

A zinc-chelating cyclic alkyl polyamine compound is efficient and safe in a murine model of multidrug-resistant Candida auris infection

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Researchers tested a new drug called APC6 that works by trapping zinc, which fungi need to survive. In mouse studies of a dangerous resistant fungus called Candida auris, APC6 saved all treated mice while most untreated mice died. The drug also reduced fungal infections in organs without causing serious side effects, suggesting it could become a new treatment option for serious fungal infections resistant to current medicines.

Green Synthesized Copper-Oxide Nanoparticles Exhibit Antifungal Activity Against Botrytis cinerea, the Causal Agent of the Gray Mold Disease

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Scientists developed tiny copper oxide particles using fungi to create a natural fungicide that fights gray mold, a disease that damages grapes and other crops worldwide. These bio-based nanoparticles work better than conventional copper fungicides, offering farmers a more environmentally friendly option. However, the particles showed some toxicity to human cells in laboratory tests, suggesting they need careful handling before field use.

Chemical profile and bioactivity of essential oils from five Turkish thyme species against white mold fungal disease agent Sclerotinia sclerotiorum

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Researchers studied five types of Turkish thyme plants to see if their essential oils could fight a harmful fungus called Sclerotinia sclerotiorum that damages crops like cucumbers and sunflowers. They found that thyme oils, especially those rich in carvacrol and thymol, were very effective at stopping fungal growth. These natural plant oils could be used as safer alternatives to chemical fungicides in farming, reducing environmental damage while controlling plant diseases.

Tinea genitalis profunda caused by Microsporum canis: A case report and literature review

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A 23-year-old woman developed a severe fungal infection in the genital area caused by a fungus normally found on dogs. Her initial antibiotic treatment failed because the infection was actually fungal, not bacterial. After diagnosis through fungal culture, she was successfully treated with antifungal medications, though the infection left some scarring and discoloration. This case highlights how genital fungal infections can be difficult to diagnose because they look similar to bacterial infections.

Saponins, the Unexplored Secondary Metabolites in Plant Defense: Opportunities in Integrated Pest Management

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Plants naturally produce compounds called saponins that protect them from insects, fungi, bacteria, parasitic worms, and viruses. This review explains how saponins work as natural pest managers and discusses how plants rich in saponins, such as licorice and soapbark trees, could be used to develop environmentally friendly crop protection products instead of synthetic pesticides.

Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris

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Researchers tested an edible mushroom called Cordyceps militaris to see if it could fight SARS-CoV-2, the virus that causes COVID-19. Using computer modeling and laboratory experiments, they found that a compound in the mushroom called cordycepin strongly attached to the virus’s spike protein and reduced viral numbers by about 50% in cell cultures. The study supports traditional uses of this mushroom and suggests it could be helpful in managing COVID-19 as the disease becomes endemic.

The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of Candida auris

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Candida auris is a dangerous fungal infection that resists many standard antifungal drugs. Researchers discovered that a protein called Gcn5 helps this fungus survive both drugs and the body’s immune system. By targeting Gcn5 with a new compound called CPTH2, scientists showed they could make the fungus more vulnerable to standard treatments like caspofungin, suggesting a promising new approach to fighting these infections.

Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans

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This research shows that an extract from the Phoenix oyster mushroom (Pleurotus pulmonarius) can boost the body’s immune cells to fight dangerous fungal infections caused by Cryptococcus neoformans. When immune cells are pre-exposed to this mushroom extract and then encounter the fungus, they become more effective at killing it through increased production of immune-signaling molecules and reactive oxygen species. This natural supplement approach offers a promising alternative to traditional antifungal drugs, which often have significant side effects and can lead to drug resistance.

Antifungal Volatile Organic Compounds from Talaromyces purpureogenus CEF642N: Insights from One Strain Many Compounds (OSMAC) Strategy for Controlling Verticillium dahliae in Cotton

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Scientists discovered that a beneficial fungus called Talaromyces purpureogenus produces natural antifungal compounds that effectively control cotton wilt disease caused by the harmful fungus Verticillium dahliae. The study identified two main compounds, 3-octanol and 2-octenal, that showed strong antifungal activity without synthetic chemicals. This research offers a promising green alternative for protecting cotton crops from one of agriculture’s major diseases while being environmentally friendly.

2-Nonanol produced by Bacillus velezensis EM-1: a new biocontrol agent against tobacco brown spot

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Researchers discovered that a beneficial bacterium called Bacillus velezensis produces a natural compound called 2-nonanol that effectively kills the fungus causing brown spots on tobacco leaves. This compound works by disrupting the fungus’s ability to obtain energy and handle stress. Testing on tobacco leaves showed that 2-nonanol could significantly reduce disease development. This discovery offers a promising environmentally-friendly alternative to chemical fungicides for protecting tobacco crops.

therapeutic action: antifungal activity