antifungal activity – Page 31

Eco-friendly biosynthesis of silver nanoparticles using marine-derived Fusarium equiseti: optimization, characterization, and evaluation of antimicrobial, antioxidant, and cytotoxic activities

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Scientists used a marine fungus called Fusarium equiseti to create tiny silver particles called nanoparticles in an environmentally-friendly way. These particles showed strong abilities to kill harmful bacteria and fungi, protect cells from damage caused by free radicals, and fight breast cancer cells in laboratory tests. This green synthesis method offers a safer, non-toxic alternative to traditional chemical manufacturing while producing stable, multi-functional nanoparticles.

Simplicillium sinense sp. nov., a novel potential pathogen of tinea faciei

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Researchers identified a new fungal species called Simplicillium sinense that caused a facial skin infection (tinea faciei) in a 46-year-old man with diabetes. The fungus was resistant to most common antifungal medications but responded well to terbinafine treatment. This is the first reported case of a Simplicillium infection causing facial ringworm, expanding our understanding of rare fungal pathogens.

Application of Nanocomposites-Based Polymers on Managing Fungal Diseases in Crop Production

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Scientists are developing tiny particles made from natural materials like chitosan to protect crops from fungal diseases. These nanoparticles work better than traditional fungicides and can be combined with metals or plant extracts to boost their effectiveness. The new approach is more environmentally friendly and can reduce crop loss caused by fungal infections while maintaining sustainable agricultural practices.

Bacillus velezensis CNPMS-22 as biocontrol agent of pathogenic fungi and plant growth promoter

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A bacterial strain called Bacillus velezensis CNPMS-22 shows promise as a natural pest control agent for crops. When applied to maize seeds, it reduced fungal diseases and increased plant productivity as effectively as chemical fungicides. The bacteria produces natural compounds that kill harmful fungi while also promoting plant growth, offering a safer, more environmentally friendly alternative to synthetic chemicals.

Synergistic effects of Cyp51 isozyme-specific azole antifungal agents on fungi with multiple cyp51 isozyme genes

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This study found that different azole antifungal drugs work better against different versions of an enzyme (Cyp51) that fungi need to survive. By combining two azole drugs that each target different enzyme versions, researchers achieved stronger antifungal effects than either drug alone. This discovery suggests a new strategy for treating stubborn fungal infections by carefully selecting drug combinations based on which enzyme versions the fungus possesses.

Staurosporine as an Antifungal Agent

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Staurosporine is a natural compound produced by soil bacteria that can kill fungi. Scientists originally discovered it in 1977 and found it works by blocking proteins called kinases that fungi need to survive. Recent research shows it could be useful against drug-resistant fungal infections, especially when combined with other antifungal medicines. However, it needs to be modified to make it safer for human use.

Isolation and Identification of Aspergillus spp. from Rotted Walnuts and Inhibition Mechanism of Aspergillus flavus via Cinnamon Essential Oil

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Researchers collected rotted walnuts from storage in Shanxi, China and identified five types of Aspergillus fungi contaminating them, with Aspergillus flavus being the most common. They tested cinnamon essential oil as a natural antifungal treatment and found it effectively stopped fungal growth by damaging the fungi’s cell membranes and causing oxidative stress. This research suggests cinnamon essential oil could be used as a safe, natural alternative to chemical fungicides for preserving walnuts and other foods from fungal spoilage.

Selection of reliable reference genes in Colletotrichum scovillei during different growth stages, host interactions, and plant extract treatment for qRT-PCR

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Researchers identified the best internal control genes for measuring fungal gene expression in Colletotrichum scovillei, a fungus that causes serious disease in chili peppers. Different genes worked best under different conditions: one for normal growth, another during infection, and a third when treated with plant extracts. This discovery will help scientists study how this fungus develops and causes disease, potentially leading to better ways to control it using natural plant-based treatments.

Biocontrol efficiency and mechanism of novel Streptomyces luomodiensis SCA4-21 against banana Fusarium wilt

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A newly discovered bacterium called Streptomyces luomodiensis SCA4-21 offers a natural solution to banana Fusarium wilt, a serious disease that destroys banana crops globally. When applied to banana plants, this beneficial bacterium reduced disease occurrence by 59% while also promoting healthier plant growth. The bacterium works by producing antifungal compounds that kill the disease-causing fungus and by enriching the soil with other helpful microorganisms that protect the plant.

Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes

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This research shows that amphotericin B, a natural compound produced by bacteria, can effectively prevent gray mold from spoiling table grapes after harvest. The compound works by damaging the mold’s cell membranes and also activates the grapes’ own defense systems. At a treatment level of 200 mg/L, it completely prevented mold growth on grapes over a three-day storage period, offering a safer, more environmentally friendly alternative to synthetic fungicides.

therapeutic action: antifungal activity