antifungal activity – Page 3

pH-responsive imine-chitosan-based intelligent controlled-release packaging films with transformable antimicrobial modes from defense to attack

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Researchers developed a smart food packaging film that fights bacteria and fungi in two different ways depending on acidity levels. When stored with neutral pH foods, the film’s surface prevents microbes from sticking to it. When the food becomes more acidic (like in tomato juice), the film releases antimicrobial compounds that actively kill the microorganisms. Tests showed it effectively preserved cherry tomatoes and tomato juice while blocking harmful UV light.

Novel Antimicrobial Activities of Albofungin, Albonoursin, and Ribonucleosides Produced by Streptomyces sp. Caat 5-35 Against Phytopathogens and Their Potential as a Biocontrol Agent

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Scientists discovered that a soil bacterium called Streptomyces sp. Caat 5-35 produces natural compounds that can kill crop-damaging pathogens. These compounds, including albofungin and albonoursin, showed strong activity against diseases affecting cacao and palm crops. The bacterium also helps plants by breaking down cellulose and making phosphorus more available, making it a promising tool for natural crop protection without synthetic chemicals.

Rice varietal intercropping mediates resistance to rice blast (Magnaporthe oryzae) through core root exudates

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Growing different varieties of rice together can help protect susceptible rice plants from blast disease. When resistant and susceptible rice varieties are planted together, the resistant plants release special chemicals from their roots that help the susceptible plants fight off the fungal disease. Scientists identified four key chemicals—azelaic acid, sebacic acid, betaine, and phenyl acetate—that work together to boost the immune system of susceptible rice plants and directly kill the blast fungus.

The Effect of Supplementing Mushroom Growing Substrates on the Bioactive Compounds, Antimicrobial Activity, and Antioxidant Activity of Pleurotus ostreatus

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This study investigated how adding wheat bran to mushroom growing substrates affects oyster mushroom quality and medicinal properties. The researchers found that wheat bran supplementation increased mushroom yield but slightly decreased antioxidant power, while the mushrooms produced antimicrobial compounds effective against various bacteria and fungi. The mushrooms contained beneficial compounds like vitamin E and phenols, suggesting they could be developed as natural alternatives to synthetic antibiotics.

Phaeohyphomycosis caused by Rhinocladiella similis mimicking Sporotrichosis

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A 34-year-old factory worker developed multiple nodules on his hand following an injury, initially suspected to be sporotrichosis, a common fungal infection. Through laboratory testing including fungal culture and genetic sequencing, doctors identified the actual cause as a rare fungus called Rhinocladiella similis. The patient was successfully treated with antifungal medication and showed gradual improvement. This is the first case of this fungal infection reported in India.

Global species diversity and distribution of the psychedelic fungal genus Panaeolus

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This study is a comprehensive catalog of 77 Panaeolus mushroom species worldwide, of which 20 are known to be hallucinogenic and contain psilocybin. Researchers found that these mushrooms are most commonly documented in Asia, South America, and Europe, but many regions have little to no research data. The review highlights significant gaps in our knowledge about where these species exist and which ones truly contain psychoactive compounds, information that is crucial as these fungi become legal in more countries for medical use.

Advanced Fungal Biotechnologies in Accomplishing Sustainable Development Goals (SDGs): What Do We Know and What Comes Next?

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Fungi are remarkable organisms with tremendous untapped potential for solving global challenges. They can be engineered to produce life-saving medicines like antibiotics and cholesterol-lowering drugs, create nutritious food alternatives, clean up polluted environments, and help fight climate change. As we transition to more sustainable living practices, fungi represent a natural solution that has been used for centuries but is only now being fully appreciated through modern biotechnology.

Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites

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Scientists have learned to use common baker’s yeast (S. cerevisiae) as a biological factory to produce valuable medicines and compounds that naturally come from fungi and mushrooms. By transferring the genetic instructions for making these compounds into yeast cells and improving them with genetic engineering, researchers can now produce therapeutically important substances like cancer-fighting drugs and antibiotics in large quantities. This approach is more practical and cost-effective than trying to extract these rare compounds directly from their native fungal sources or using other production methods.

Synergistic curative effects of Trichoderma hamatum and Rumex dentatus against Alternaria alternata, the causal agent of tomato leaf spot disease

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This research discovered that combining a beneficial fungus called Trichoderma hamatum with an extract from Rumex dentatus plant effectively controls tomato leaf spot disease. When used together, these natural treatments reduced disease by over 88% and even outperformed commercial fungicides. The combined treatment also boosted plant health by increasing growth and natural defense mechanisms, offering farmers an affordable and environmentally safe alternative to chemical pesticides.

Experimental research on fungal inhibition using dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase

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Researchers developed a new patch treatment for nail fungus using tiny dissolving needles that deliver antifungal medication directly into the skin near infected nails. The patch combines two active ingredients that work together to kill fungus and break down protective biofilm layers that make fungal infections hard to treat. Testing showed the patch was safe, effective, and delivered much more medication to the infected area compared to traditional creams or pills.

therapeutic action: antifungal activity