antifungal activity – Page 29

Biocontrol Potential of a Mango-Derived Weissella paramesenteroides and Its Application in Managing Strawberry Postharvest Disease

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Researchers discovered that a beneficial bacteria called Weissella paramesenteroides, naturally found on mango surfaces, can protect strawberries from fungal spoilage. This bacteria works by releasing special aromatic compounds (VOCs) into the air that kill disease-causing fungi without direct contact. When used in strawberry storage boxes, this biocontrol method reduced fruit disease from 70% to 35%, offering a safer, natural alternative to synthetic fungicides.

Superhydrophobic Fatty Acid-Based Spray Coatings with Dual-Mode Antifungal Activity

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Scientists developed easy-to-apply spray coatings made from natural fatty acids that repel water and kill fungal infections like gray mold. By combining long-chain fatty acids with shorter fatty acids like those found in food preservatives, the coatings can either passively prevent fungus from sticking to surfaces or actively kill it. These coatings are environmentally friendly, sustainable alternatives to chemical fungicides that fungi are becoming resistant to, and could be used to protect everything from building surfaces to stored crops.

A Rare Case of Alternaria citri Keratitis Successfully Treated with Voriconazole

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A 71-year-old woodworker developed a serious eye infection caused by a rare fungus called Alternaria citri that damaged his cornea. Doctors identified the fungus using genetic testing and treated it with the antifungal drug voriconazole combined with surgery. After one year, his vision improved and the infection did not return, marking the first documented case of this particular fungal infection in humans.

Nano Emulsion of Essential Oils Loaded in Chitosan Coating for Controlling Anthracnose in Tomatoes (Solanum lycopersicum) During Storage

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Researchers developed a natural coating made from chitosan (a biopolymer) and thyme essential oil nano particles to protect tomatoes from a fungal disease called anthracnose during storage. When applied to tomatoes, this coating reduced disease occurrence by 50%, outperforming the commercial fungicide currently used. This eco-friendly solution offers a sustainable alternative to synthetic chemical treatments while maintaining tomato quality for longer periods.

Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites

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Researchers tested 18 types of medicinal mushrooms to see if they could produce natural antibiotics. Most of them (16 out of 18) showed antimicrobial properties, with some being particularly effective against dangerous bacteria and fungi. The most promising mushroom strain (Hericium corraloides 4) showed strong activity against multiple disease-causing organisms. This research suggests that mushrooms could be valuable sources for developing new antibiotics to fight drug-resistant infections.

Fungal inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta

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Researchers isolated six antifungal compounds from a traditional Chinese medicine plant called Laggera pterodonta. One compound called costic acid showed excellent ability to kill common crop-destroying fungi like P. nicotianae and F. oxysporum by damaging their cell membranes. These natural compounds could serve as safer alternatives to synthetic fungicides in agriculture, offering environmental benefits without toxic chemical residues.

Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review

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A 74-year-old man developed painful red masses on his arm and hand after being stuck by a tree branch. Tests identified the infection was caused by a fungus called Sporothrix schenckii. Despite having a normal immune system, the infection had spread across his arm in an unusual pattern. Treatment with an antifungal medication called itraconazole completely healed the lesions within four months without any scarring.

In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species

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Researchers tested an old antibiotic called nitroxoline against dangerous fungal infections caused by Aspergillus species. The drug works by removing essential zinc that the fungus needs to survive. The study found that nitroxoline was highly effective against all tested fungal strains, including those resistant to modern antifungal drugs, suggesting it could be a promising alternative treatment for serious fungal infections.

Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model

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Researchers developed tiny nanoparticle carriers coated with a fungal enzyme that helps them cross the protective barrier around the brain. These particles were loaded with an antifungal drug to treat brain infections caused by Cryptococcus neoformans. In laboratory tests, the Mpr1-coated particles successfully penetrated the blood-brain barrier better than regular nanoparticles and were more effective at killing the fungal cells.

Characterization of a bacterial strain T226 and its efficacy in controlling post-harvest citrus anthracnose

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Researchers identified a beneficial bacterium called Lysobacter enzymogenes (strain T226) that effectively prevents citrus fruit rot caused by anthracnose fungus. This bacterium was isolated from soil and showed stable antimicrobial properties even after repeated culture transfers. When applied to citrus fruits, it reduced disease incidence by over 61% under natural storage conditions, performing better than the chemical fungicide prochloraz, making it a promising eco-friendly alternative for protecting stored citrus.

therapeutic action: antifungal activity