antifungal activity – Page 28

Pathogen identification and biological fungicides screening for Plumbago auriculata blight in China

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Researchers identified a fungal pathogen (Fusarium ipomoeae) causing a serious disease in Plumbago auriculata ornamental plants in China. They tested seven biological fungicides and found that osthole was the most effective at preventing the disease. The study provides gardeners and farmers with an environmentally friendly solution to control this plant disease using a natural compound.

Microbial-Based Green Synthesis of Silver Nanoparticles: A Comparative Review of Bacteria- and Fungi-Mediated Approaches

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Scientists have developed environmentally friendly ways to create tiny silver particles using bacteria and fungi instead of harsh chemicals. These silver nanoparticles can fight bacteria, help treat cancer, clean contaminated water, and improve food packaging. The review shows that bacteria produce particles quickly but fungi are better for large-scale production and create more stable particles.

Clinical Mycology Today: Emerging Challenges and Opportunities

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Fungal infections are becoming more common due to new cancer treatments and other medical advances, while some fungal species are developing resistance to standard antifungal medications. The good news is that several new antifungal drugs are in development with better safety profiles and novel mechanisms to fight these infections. However, the field faces challenges including limited specialized mycologists and difficulty designing clinical trials to properly test new treatments.

The in vitro Activity of Echinocandins Against Clinical Trichophyton rubrum Isolates and Review of the Susceptibility of T. rubrum to Echinocandins Worldwide

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Researchers tested how well three antifungal drugs (micafungin, anidulafungin, and caspofungin) work against a common fungus that causes skin infections. They found that two of these drugs were more effective than the third, suggesting they could be helpful alternatives when standard treatments fail due to drug-resistant fungal strains. The study also reviewed similar research worldwide and found consistent results across different testing methods.

A Case Report of Candidiasis Cellulitis in Long-Term Corticosteroid Use

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A 54-year-old man developed a serious hand infection caused by Candida albicans, a yeast that normally lives harmlessly on human skin. The infection occurred because he had been taking large doses of corticosteroid injections for 15 years to help with breathing problems, which weakened his immune system. Doctors drained the infected area and treated him with antifungal medication, and he recovered completely, highlighting the importance of recognizing fungal infections in patients on long-term steroid therapy.

Epidermophyton floccosum, an etiological agent of tinea pedis and tinea unguium: about two cases

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Two elderly patients with toenail and foot fungal infections caused by Epidermophyton floccosum were diagnosed using modern molecular testing methods. Traditional microscopic examination alone was difficult, but real-time PCR provided accurate identification. Both patients were treated with terbinafine, a common antifungal medication. The study highlights how modern DNA testing improves diagnosis compared to older methods.

Drug repurposing to fight resistant fungal species: Recent developments as novel therapeutic strategies

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This editorial highlights the growing problem of fungal infections that resist current treatments, causing millions of deaths worldwide each year. Researchers are finding new ways to fight these resistant infections by repurposing existing drugs in new combinations and discovering novel compounds from natural sources. The collection of studies presented shows promising results using combinations like minocycline with antifungal drugs, natural compounds like baicalin, and AI technology to predict resistance patterns. These innovative approaches offer hope for better treatment options for patients suffering from serious fungal infections.

Design, synthesis, and antimicrobial evaluation of novel 1,2,4-triazole thioether derivatives with a 1,3,4-thiadiazole skeleton

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Scientists created 17 new chemical compounds that can fight harmful fungi and bacteria that damage plants. One of these compounds, called 9d, proved to be even more effective than existing commercial pesticides at fighting plant diseases. Tests on kiwifruit showed that this new compound could protect and treat bacterial infections better than currently available treatments. These new compounds could help protect crops and reduce reliance on older pesticides.

Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child

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A young girl contracted a dangerous drug-resistant fungal infection in her knee after an injury, which failed to respond to standard antifungal treatments. Doctors obtained special access to an experimental antifungal drug called olorofim through a compassionate use program. The child showed improvement within two weeks and was completely cured after six months of treatment with no signs of the infection returning two years later, making this the first successful case of this new drug being used in a child.

Caspofungin therapy in prosthetic valve endocarditis and candidemia due to itraconazole-resistant Candida glabrata (Nakaseomyces glabratus): A case report

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A 13-year-old boy developed a serious fungal infection of his heart valve after surgery. The infection was caused by a resistant yeast that didn’t respond to initial antifungal treatment. Doctors used molecular testing to identify the exact fungal species and tested how it responded to different medications. After switching to a different antifungal drug called caspofungin, the patient recovered completely and remained healthy.

therapeutic action: antifungal activity