antifungal activity – Page 26

Endocarditis caused by Scopulariopsis brevicaulis with disseminated emboli and multiple vascular aneurysms: A case report and literature review

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A 61-year-old man with a prosthetic aortic valve developed a rare fungal infection caused by Scopulariopsis brevicaulis, a mold usually associated with nail infections. The infection spread throughout his body, causing multiple strokes and aneurysms that required emergency surgery and treatment with various antifungal medications. This case highlights the serious complications that can occur when this typically harmless fungus invades the heart and demonstrates the challenges doctors face in treating such rare infections, as the fungus was resistant to many common antifungal drugs.

Evaluating the Role of Nutrient Competition in Debaryomyces hansenii Biocontrol Activity Against Spoilage Molds in the Meat Industry

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This research examined how a beneficial yeast called Debaryomyces hansenii prevents dangerous molds from growing on cured meat products. Scientists compared different strains of this yeast and tested whether it works by competing with molds for nutrients. While the yeast successfully stopped mold growth and spore production, nutrient competition wasn’t the main reason—other mechanisms like direct interactions between the microorganisms were more important. This suggests D. hansenii could be a natural alternative to chemical preservatives in the meat industry.

Trichosporon species bloodstream infections in a tertiary care hospital in the western region of Saudi Arabia: A 7-year retrospective chart review from 2016 to 2022

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This study examined a rare but dangerous fungal infection called Trichosporonosis that affects the bloodstream in hospitalized patients. Researchers found that this infection kills about 60% of patients despite treatment with antifungal medications. The infection is often caused by a fungus called Trichosporon asahii and typically occurs in patients with weakened immune systems who are already hospitalized and using catheters.

Antifungal effect of soil Bacillus bacteria on pathogenic species of the fungal genera Aspergillus and Trichophyton

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Researchers discovered that four types of Bacillus bacteria found in soil can effectively kill dangerous fungi that cause infections in humans. These bacteria produce natural compounds that inhibit fungal growth even better than some standard antifungal medications. This discovery is particularly important because many fungi are becoming resistant to current drugs, making these soil bacteria a promising natural alternative for treating fungal infections.

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Graphene nanomaterials, especially nano-graphene oxide, show promise as new treatments for serious lung fungal infections that particularly threaten people with weakened immune systems. These tiny materials work by generating damaging reactive oxygen species that kill fungal cells and prevent biofilm formation. Unlike traditional antifungal drugs, nano-graphene oxide can be delivered directly to infected lung tissue via inhalation, delivering medicine exactly where needed while reducing harmful side effects throughout the body.

Inhibitory Effects of Origanum vulgare Essential Oil on Mycogone perniciosa Growth in Agaricus bisporus Cultivation

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A new study shows that oregano essential oil can effectively prevent and treat wet bubble disease in button mushrooms, a fungal infection that costs farmers millions in crop losses. The oil works better than conventional chemical fungicides and contains powerful antifungal compounds like carvacrol and thymol. When applied at the right time, oregano oil completely stopped the disease from developing while maintaining healthy mushroom yields. This natural solution could help organic mushroom farmers reduce their reliance on synthetic chemicals.

Antagonistic Potential of Agro-Industrial Byproduct–Derived Lactic Acid Bacteria Against Mycotoxigenic Aspergillus flavus and Fusarium verticillioides

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Researchers discovered that certain lactic acid bacteria found in food waste products can effectively prevent the growth of harmful fungi and block the production of dangerous mycotoxins. These bacteria work through multiple mechanisms including acidification and production of protective compounds. The findings suggest these natural bacteria could be used as safe, sustainable alternatives to chemical fungicides in food preservation and safety.

Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

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Researchers extracted and identified six chemical compounds from A. blazei mushrooms and tested their ability to fight fungal infections. The compounds showed promising activity against common fungal pathogens that cause infections in humans. This research suggests that A. blazei could be developed into natural antifungal treatments. The findings add to growing evidence that medicinal mushrooms contain valuable bioactive compounds with therapeutic potential.

Phaeoacremonium iranianum – a new corneal pathogen

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A 66-year-old man developed a serious eye infection from a fungus called Phaeoacremonium iranianum after his eye was scratched by a leaf. This is the first reported case of this fungus causing a corneal infection. Doctors treated the infection with antifungal eye drops and surgery to remove infected tissue, and the patient’s condition improved over time, though with some permanent scarring of the cornea.

The efficacy of luliconazole and caspofungin on planktonic and biofilm of Candida albicans from different sources

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Candida albicans, a common yeast infection organism, can form tough protective structures called biofilms that resist antifungal medications. This study tested two antifungal drugs (luliconazole and caspofungin) against Candida in both regular form and biofilm form. The results showed that while these drugs work well against regular Candida cells, they are much less effective against biofilms, which require 15-171 times higher doses to be inhibited. The strongest biofilms came from vaginal infections, suggesting that different infection types may require different treatment approaches.

therapeutic action: antifungal activity