antifungal activity – Page 24

Secretion of antifungal metabolites contributes to the antagonistic activity of Talaromyces oaxaquensis

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Researchers discovered that a fungus called Talaromyces oaxaquensis, found naturally in banana plants, produces powerful antifungal chemicals that kill the banana disease pathogen Fusarium oxysporum. The study identified specific compounds, particularly one called 15G256α, that damage the fungal cell wall of the pathogen. This discovery suggests a natural way to protect banana crops from a devastating disease that threatens global banana production.

Recent innovations and challenges in the treatment of fungal infections

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Fungal infections are becoming more common and harder to treat due to drug resistance, especially in people with weakened immune systems. Current antifungal medications are becoming less effective because fungi are adapting to resist them, and these drugs can cause serious side effects. Scientists are developing new treatment strategies using combinations of existing drugs, engineered biological approaches, and specially designed delivery systems to overcome resistance and improve patient outcomes.

Bacillus velezensis CNPMS-22 as biocontrol agent of pathogenic fungi and plant growth promoter

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This research demonstrates that a beneficial bacterium called Bacillus velezensis CNPMS-22 can effectively protect maize plants from fungal diseases caused by Fusarium verticillioides. When used to treat seeds before planting, this bacterium reduced disease symptoms and increased crop yield to levels comparable with chemical fungicides. The bacteria produces natural compounds that kill harmful fungi and promote plant growth, offering a safer and more sustainable alternative to chemical pesticides.

Extraction and Identification of the Bioactive Metabolites Produced by Curvularia inaequalis, an Endophytic Fungus Collected in Iran from Echium khuzistanicum Mozaff

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Scientists discovered a beneficial fungus living inside the leaves of an Iranian medicinal plant. They isolated three compounds from this fungus, with the main compound showing powerful activity against drug-resistant bacteria and plant-damaging fungi. This discovery suggests that beneficial fungi within plants could be valuable sources for developing new medicines and natural pesticides.

Fungal-fungal cocultivation alters secondary metabolites of marine fungi mediated by reactive oxygen species (ROS)

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Researchers discovered that when two types of ocean fungi grow together, one of them produces a protective chemical called alternariol that can kill bacteria and cancer cells. This happens because the fungi recognize each other as competitors and trigger special stress signals that activate defensive chemical production. Interestingly, fungi from the ocean respond differently than those from land, suggesting they have evolved unique survival strategies for harsh marine environments.

Study of the Antagonism of Biocontrol Strains Against the Blue-Stain Fungus of Rubberwood

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Rubberwood commonly develops blue staining from fungi, which reduces its value. Scientists isolated two beneficial fungi from rubberwood that can prevent this staining by competing with the harmful fungus. Testing showed that one beneficial fungus, Trichoderma reesei, works better than the other and could be used as a natural treatment to protect rubberwood from blue staining without damaging the wood.

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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This study examined fungal infections of the mouth in HIV-positive patients in Indonesia. Researchers identified different types of Candida fungi and tested how well common antifungal medications worked against them. While most medications were effective, they found some cases of drug resistance, suggesting the importance of proper testing to choose the best treatment for each patient.

Antifungal efficacy of caffeic acid and nano-caffeic acid particles against candidiasis: an in vitro study

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Researchers developed a nano-particle form of caffeic acid, a natural compound found in coffee and tea, to treat oral yeast infections (candidiasis). The nano-version showed better antifungal activity than regular caffeic acid, though not as strong as prescription antifungal drugs. Since it comes from plants with fewer side effects, it could offer an alternative treatment option for patients with candidiasis.

The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients

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Scientists tested a new nano-formulation of the antifungal drug amphotericin B against a dangerous fungus (Rhizopus arrhizus) that infected COVID-19 patients with mucormycosis. The nanoliposomal version of the drug worked much better than regular amphotericin B and other antifungal medications currently used, showing much lower concentrations needed to kill the fungus. This research suggests the new nano-formulation could be a more effective treatment option for patients with this serious COVID-19 related fungal infection.

In vitro and In silico investigation deciphering novel antifungal activity of endophyte Bacillus velezensis CBMB205 against Fusarium oxysporum

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Researchers isolated a beneficial bacteria called Bacillus velezensis from medicinal plants that can fight against a dangerous fungus causing banana wilt disease. Through laboratory and computer studies, they identified two natural compounds produced by this bacteria that stop the fungus from growing by damaging its cell walls. This discovery offers a promising eco-friendly alternative to chemical fungicides for protecting banana crops worldwide.

therapeutic action: antifungal activity