antifungal activity – Page 23

Clinical aspects and recent advances in fungal diseases impacting human health

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Fungal infections are becoming a major health threat, affecting over a billion people worldwide. The main problems are difficulty diagnosing these infections, increasing resistance to current medications, and limited treatment options. Doctors and the public need better awareness, and new antifungal drugs with different approaches are needed to effectively treat resistant infections.

Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model

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Researchers developed special nanoparticles that can cross the protective barrier surrounding the brain by using a protein from a fungal infection. These nanoparticles are loaded with an antifungal drug and can effectively treat cryptococcal brain infections in laboratory tests. This approach offers a new way to deliver medicines to the brain without invasive procedures, potentially helping patients with serious brain infections that are currently difficult to treat.

Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action

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Ganoderma is a medicinal mushroom that has been used in traditional medicine for thousands of years and shows promise as a natural antibiotic. The mushroom contains special compounds like polysaccharides and triterpenoids that can kill harmful bacteria and fungi by damaging their cell walls and boosting your immune system. Recent research shows it works against common infections like those caused by staph bacteria and E. coli, and may even help fight antibiotic-resistant germs.

Comparative Study and Transcriptomic Analysis on the Antifungal Mechanism of Ag Nanoparticles and Nanowires Against Trichosporon asahii

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Researchers compared two types of tiny silver particles (nanoparticles and nanowires) as potential treatments for a dangerous fungal infection caused by Trichosporon asahii. Silver nanowires were found to be more effective than nanoparticles at killing the fungus by damaging its cell membranes and disrupting its energy production. The study identified 15 key genes involved in how silver nanowires attack the fungus, suggesting these nanomaterials could become useful alternatives to traditional antifungal drugs.

Inhibitive effect of Urginea epigea methanolic extract and silver/zinc oxide nanoparticles on Aspergillus and aflatoxin production

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Scientists tested a plant called Urginea epigea and special tiny particles made of silver and zinc to stop a dangerous fungus called Aspergillus flavus from growing and producing aflatoxins, which are harmful poisons found in food. When used at the right concentration, the plant extract completely stopped the fungus from growing. The treatment worked by turning off the fungus’s ability to make the poison by reducing the activity of specific genes. This natural approach could offer a safer alternative to chemical fungicides for protecting our food supply.

Inhibition Mechanism of Cinnamomum burmannii Leaf Essential Oil Against Aspergillus flavus and Aflatoxins

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Researchers found that cinnamon leaf essential oil is highly effective at stopping a harmful fungus called Aspergillus flavus from growing and producing dangerous toxins called aflatoxins that contaminate stored foods like peanuts. The essential oil works by damaging the fungus’s cell membranes, disrupting its energy production, and triggering harmful stress responses within the fungal cells. This natural approach offers a safe, environmentally friendly alternative to chemical fungicides for protecting stored food crops from fungal contamination.

Tinea genitalis profunda caused by Microsporum canis: A case report and literature review

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A 23-year-old woman developed a severe fungal infection in her genital area caused by a fungus typically found in dogs. The infection initially appeared bacterial and did not respond to antibiotics. Fungal cultures identified Microsporum canis, which was successfully treated with oral antifungal medications, though the patient experienced some scarring and pigmentation changes.

Systematic Review of Tinea Nigra: A Clinical Approach

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Tinea nigra is a rare fungal skin infection that causes dark spots, usually on the palms, and is most common in tropical regions. It primarily affects younger people and women. The infection is easily diagnosed using microscopic examination and treated successfully with topical antifungal creams like ketoconazole or Whitfield’s ointment, typically clearing within 4 weeks.

Staurosporine as an Antifungal Agent

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Staurosporine is a natural compound from soil bacteria that can kill fungal infections. While originally known for its anti-cancer properties, scientists have recently rediscovered its strong antifungal activity, especially against dangerous drug-resistant fungi. The challenge is that it also damages human cells, but researchers are developing improved versions and combination treatments to make it safer and more effective.

A case report of childhood onychomycosis caused by the rare yeast Kodamaea ohmeri

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A 5-year-old girl in Vietnam developed a nail infection caused by a rare yeast called Kodamaea ohmeri, which typically affects adults with diabetes or weak immune systems. The infection, appearing as white discoloration on the nails, was successfully treated with a topical antifungal cream applied three times daily for one month. This is the first reported case of this rare yeast causing nail infection in a child in Vietnam, and it demonstrates that topical treatment can be effective for fungal nail infections in children whose nails are thinner than adults.

therapeutic action: antifungal activity