antifungal activity – Page 20

Breaking down biofilms across critical priority fungal pathogens: proteomics and computational innovation for mechanistic insights and new target discovery

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This comprehensive review examines how scientists are fighting dangerous fungal infections that form protective biofilms resistant to current antifungal drugs. Researchers are using advanced protein analysis techniques (proteomics) and artificial intelligence-based computational tools to identify new targets for drug development against four critical fungal pathogens that cause life-threatening infections like meningitis and lung infections. By combining these technologies, scientists can better understand how these fungal biofilms form and develop more effective treatments.

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

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Chitin, a natural material found in crab shells and mushrooms, can be used to make wound dressings that speed up healing and fight infection. The review compares these two sources, finding that crab-derived chitin has been studied more extensively and has several commercial products available, while mushroom-derived chitin offers advantages like lower cost and easier processing. Both types work by promoting cell growth, stopping bleeding, and killing bacteria, making them promising alternatives to traditional wound dressings for treating difficult-to-heal wounds.

Mycosynthesis of Metal-Containing Nanoparticles—Synthesis by Ascomycetes and Basidiomycetes and Their Application

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Scientists have discovered that common fungi like mushrooms and molds can produce tiny nanoparticles that fight bacteria, kill cancer cells, and speed up chemical reactions. This fungal method is much cheaper, safer, and more environmentally friendly than traditional chemical production methods. The nanoparticles can be used in medical treatments, wound dressings, water purification, and farming as natural fertilizers and pesticides.

Sandalwood Sesquiterpene (Z)-α-Santalol Exhibits In Vivo Efficacy Against Madurella mycetomatis in Galleria mellonella Larvae

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Researchers tested sandalwood oil components against a fungal disease called eumycetoma that causes serious skin infections, especially in tropical regions. They found that one component called (Z)-α-santalol was highly effective at killing the fungus and extending survival in laboratory-infected moth larvae, while actually being relatively safe. This natural compound shows promise as a potential new treatment for this neglected disease that currently relies on expensive drugs that are only 40% effective.

The Effect of Topical Ketoconazole and Topical Miconazole Nitrate in Modulating the Skin Microbiome and Mycobiome of Patients With Tinea Pedis

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This study examined how two common antifungal creams (ketoconazole and miconazole) affect the complex community of bacteria and fungi living on the skin of people with athlete’s foot. Both treatments effectively reduced the harmful fungus causing the infection and improved symptoms, with ketoconazole working slightly faster. However, the researchers found that while these treatments reduced the disease-causing fungus, the skin’s normal microbial community did not fully recover to a healthy state, particularly in the spaces between the toes.

Ultrasound-Assisted Preparation of Chitosan Oligosaccharide-Stabilized Thyme Oil-in-Water Nanoemulsions: Enhanced Storage Stability and Antimicrobial Properties

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Researchers created tiny droplets of thyme oil mixed in water using sound waves and a natural stabilizer from shellfish shells. These droplets stayed stable for weeks without separating and worked twice as well at fighting bacteria and mold compared to regular thyme oil. The new formula could be used to keep fresh food from spoiling during storage.

Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis

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An 18-year-old boy with acute leukemia developed a serious fungal infection caused by Fusarium mold that spread throughout his body, including to both eyes. Despite receiving intensive antifungal medications injected directly into his eyes along with systemic treatment, he lost his vision. However, through aggressive combined therapy, doctors were able to save both eyes and continue his cancer treatment successfully.

Anticancer drugs targeting topoisomerase II for antifungal treatment

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Researchers found that several anticancer drugs commonly used to treat human cancers can also effectively kill fungal infections, especially resistant strains of Candida. The most promising drug, idarubicin, works by targeting an essential enzyme in fungi called topoisomerase II, causing DNA damage and cell death. This discovery suggests a new strategy for treating serious fungal infections by repurposing existing cancer medications, particularly for patients with drug-resistant infections.

Excellent anti-mildew effect of essential oil impregnation on sliced veneer plybamboo and its anti-mildew mechanism

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Researchers discovered that clove essential oil is highly effective at preventing mold growth on decorative bamboo veneer materials. The natural oil damages fungal cell membranes and disrupts their internal chemistry, killing the mold without toxic chemicals. When bamboo sheets were treated with clove oil before assembly, they showed excellent resistance to common molds. This provides a green, sustainable alternative to harsh chemical treatments while maintaining product quality.

Genomic Insights of Candida krusei, an Emerging Fungal Pathogen With Intrinsic Antifungal Resistance

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Candida krusei is a yeast that causes serious bloodstream infections, particularly in people with weakened immune systems. Unlike many other fungi, it naturally resists common antifungal drugs like fluconazole, making infections hard to treat. The organism can form protective biofilms and has multiple genetic mechanisms that help it survive antifungal treatment. Researchers are exploring new drugs and treatment strategies to combat this growing health threat, especially in hospitals.

therapeutic action: antifungal activity