antifungal activity – Page 17

Endophytic Diversity in Sicilian Olive Trees: Identifying Optimal Conditions for a Functional Microbial Collection

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Researchers studied beneficial bacteria and fungi living inside olive trees from Sicily to create a collection of microorganisms that could improve olive farming. They found that wild olive trees and samples collected in winter had the most diverse and beneficial microbes, and that organic farming practices supported greater microbial diversity. Some of these microbes, especially Bacillus bacteria, showed promise in fighting fungal diseases and promoting plant growth, offering potential for developing natural fertilizers and disease control methods.

Peritoneal dialysis-related peritonitis caused by Fusarium: a case report and literature review

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A 61-year-old farmer with kidney disease on peritoneal dialysis developed a rare fungal infection caused by Fusarium, a fungus found in soil and water. After initial antibiotics failed, doctors identified the fungus and switched to an antifungal medication called voriconazole. By carefully monitoring drug levels in the patient’s blood and adjusting doses, pharmacists helped achieve a successful recovery with complete resolution of symptoms.

Evaluation of the Cytotoxicity and Antifungal Efficacy of Crocus sativus (saffron) Petals on Clinical Isolates of Candida albicans

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Researchers tested saffron petals as a natural antifungal treatment against Candida albicans, a common fungal infection. While the saffron extract was less potent than the standard drug fluconazole, it showed promise as a safer alternative with minimal toxicity to human cells. The findings suggest saffron petals could be a cost-effective herbal option for treating fungal infections, especially as resistance to conventional antifungals increases.

An Efficient Microwave Synthesis of 3-Acyl-5-bromoindole Derivatives for Controlling Monilinia fructicola and Botrytis cinerea

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Scientists created new chemical compounds based on indole structures that can kill harmful fungi that destroy fruit crops. These compounds were made more efficiently using microwave heating and tested against two major crop pathogens that cause billions of dollars in losses annually. The most promising compound (A) proved even more effective than commercial fungicides at stopping fungal growth and spore germination. This research could lead to better, safer alternatives for protecting crops from fungal diseases.

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

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This research reveals that disabling certain cell division checkpoint proteins in the fungus Aspergillus fumigatus creates populations resistant to triazole antifungal drugs. The resistant fungal cells appear to have abnormal amounts of genetic material, suggesting that loss of these checkpoint controls allows cells with extra chromosomes to survive drug exposure. This discovery provides new insight into how dangerous fungal infections can develop resistance to our most important antifungal treatments.

In Vitro Screening of the Antifungal and Antimycotoxin Effects of a Stilbenoids-Rich Grapevine Cane Extract on Fusarium graminearum, Aspergillus flavus and Penicillium expansum

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This study tested a natural extract from grapevine pruning waste to see if it could stop three dangerous fungi that produce harmful toxins in crops. The extract worked well at stopping both fungal growth and toxin production, with effects that lasted even after the extract was removed. These results suggest that grapevine waste could be turned into a natural fungicide to protect crops from contamination.

Antifungal mechanism of nanosilver biosynthesized with Trichoderma longibrachiatum and its potential to control muskmelon Fusarium wilt

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Researchers created tiny silver particles using a beneficial fungus to fight a serious disease that damages muskmelon plants. At low doses, these silver nanoparticles killed the disease-causing fungus while actually helping the melon plants grow better and germinate faster. The silver particles work by damaging the fungus’s cell structure and triggering harmful reactive oxygen species inside fungal cells, ultimately destroying them.

Nature-Inspired Biphenyls and Diphenyl Ethers: Design, Synthesis, and Biological Evaluation

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Researchers synthesized compounds inspired by naturally occurring substances found in brown algae called phlorotannins. These synthetic compounds were tested against fungi that damage rice crops and other plants. Some methylated versions showed promise in slowing fungal growth, suggesting they could potentially be developed into new natural fungicides. However, the compounds were not effective against bacteria, indicating more research is needed.

Algae and Cyanobacteria Fatty Acids and Bioactive Metabolites: Natural Antifungal Alternative Against Fusarium sp

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This review examines how fatty acids and other compounds from algae and cyanobacteria can naturally fight Fusarium fungus, which damages crops like wheat, corn, and tomatoes. Traditional chemical fungicides harm the environment and can make fungi resistant, so scientists are exploring algae-based alternatives that work sustainably. The research shows these algal compounds can damage fungal cell membranes and boost plant defenses against infection. While promising, more work is needed to develop these natural solutions for practical farm use.

Cultivation and mycelium production from spore suspensions of desert truffles: prospective use as inoculum for host plants in arid zones

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Scientists successfully grew two types of desert truffles from Morocco in the laboratory using simple growth materials. By placing spores in potato dextrose agar or malt extract agar, they were able to produce substantial amounts of fungal threads (mycelium) within a week. This achievement is important because these truffles can now be used to help restore desert soils and grow edible mushrooms in arid regions, providing food and income for communities while fighting desertification.

therapeutic action: antifungal activity