antifungal activity – Page 16

Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance in Candida glabrata

mycolabadmin

Candida glabrata is a dangerous fungus causing serious infections that is becoming resistant to antifungal drugs. Researchers used a genetic screening technique to find genes that interact with drug resistance mutations and identified methotrexate (a drug already used for arthritis) as a potential partner for fluconazole treatment. When combined, these drugs work better together against resistant strains of the fungus, offering hope for treating these stubborn infections.

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

mycolabadmin

Fungal lung infections are a serious problem, especially for people with weak immune systems. Researchers are exploring graphene nanomaterials as a new treatment approach that can deliver antifungal drugs directly to infected areas in the lungs. These tiny particles work by creating toxic stress inside fungal cells and breaking down their protective biofilms, while using smaller drug doses and causing fewer side effects than traditional treatments.

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

mycolabadmin

Researchers tested five compounds called naphthoquinones for their ability to fight a dangerous fungal infection called cryptococcosis. They found that one compound called 2-MNQ works especially well when combined with the standard antifungal drug amphotericin B, making the treatment more effective. This discovery could lead to better treatments for people with weakened immune systems who are vulnerable to this infection.

Essential Oils as an Antifungal Alternative to Control Several Species of Fungi Isolated from Musa paradisiaca: Part III

mycolabadmin

This research tested six common cooking and medicinal herbs to see which could stop the growth of fungi that spoil bananas after harvest. Scientists found that thyme oil was the most effective, followed by cinnamon and oregano, successfully preventing fungal growth at practical concentrations. These natural oils could replace synthetic chemical fungicides that harm the environment, offering a safer way to keep bananas fresh and healthy during storage and transport.

Superficial Fungal Infections in Children—What Do We Know?

mycolabadmin

Superficial fungal infections like ringworm and athlete’s foot are common in children and are caused by fungi, yeasts, or molds that spread through contact with infected people, animals, or contaminated surfaces. These infections primarily affect the scalp, skin, and nails, with scalp infections being most common in young children. Treatment typically uses topical creams for mild cases or oral medications for more severe infections, particularly those affecting nails or the scalp. Proper hygiene, avoiding contaminated areas, and limiting contact with infected individuals or animals are key to prevention.

Antifungal Effects of the Phloroglucinol Derivative DPPG Against Pathogenic Aspergillus fumigatus

mycolabadmin

Scientists developed a new antifungal compound called DPPG based on a natural antibacterial molecule produced by soil bacteria. This synthetic derivative showed strong activity against dangerous fungal pathogens like Aspergillus fumigatus and Candida species, which cause serious infections in humans. The compound works by disrupting the fungal cell membrane, causing it to leak and die. Testing in insect models demonstrated effectiveness comparable to current clinical antifungal medications.

Antifungal effect of soil Bacillus bacteria on pathogenic species of the fungal genera Aspergillus and Trichophyton

mycolabadmin

Scientists found that certain bacteria naturally occurring in soil can effectively kill harmful fungi that cause infections in humans. By isolating and testing different Bacillus bacteria species, researchers discovered that some were even more effective at inhibiting fungal growth than commonly used antifungal medications. This finding suggests a promising natural alternative to combat fungal infections, especially as many fungi are becoming resistant to traditional antifungal drugs.

Nature-Inspired Biphenyls and Diphenyl Ethers: Design, Synthesis, and Biological Evaluation

mycolabadmin

Scientists created synthetic versions of protective compounds found in brown seaweed that could potentially be used as natural fungicides. They designed and synthesized fifteen different chemical derivatives and tested them against harmful plant fungi that damage crops. While the chemically modified versions showed modest effectiveness at stopping fungal growth, the naturally occurring compounds had little effect, suggesting that chemical alterations play an important role in fighting crop diseases.

Antifungal Potential of Streptomyces-Derived Metabolites Against Fluconazole-Resistant Oral Candida albicans: In vitro Evaluation and Mechanistic Insights

mycolabadmin

Researchers studied a type of soil bacteria called Streptomyces that produces natural compounds with strong antifungal properties. These compounds effectively killed drug-resistant Candida fungal infections that commonly affect cancer patients undergoing radiation therapy. The bacterial extract worked by damaging fungal cell membranes and blocking biofilm formation, which are protective structures the fungus uses to survive. While the results are promising for treating stubborn fungal infections, more research is needed to ensure safety for human patients.

Mesoporous silica and vegetal extracts combined as sustainable stone heritage protection against biodeterioration

mycolabadmin

Researchers developed an innovative protective coating for historic stone structures using natural plant extracts encapsulated in special porous silica particles. The oregano oil-based coating successfully prevented fungal growth on marble surfaces for extended periods while being safe for the environment and workers. This sustainable solution offers museums and heritage conservation professionals a non-toxic alternative to harsh chemical biocides, helping preserve precious artifacts for future generations.

therapeutic action: antifungal activity