antifungal activity – Page 13

Severe Saprochaete capitata fungemia presenting as micafungin breakthrough hepatosplenic lesions in an immunocompromised patient: case report

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A 70-year-old woman with blood cancer developed a serious fungal blood infection caused by Saprochaete capitata, a rare soil fungus, despite taking preventive antifungal medication. The infection spread to her liver and spleen, creating multiple lesions and a dangerous aneurysm. Doctors successfully treated her with a combination of three antifungal drugs, particularly voriconazole, which proved more effective than the initial preventive medication. This case highlights how rare fungi can cause severe infections in cancer patients and the importance of recognizing when standard preventive treatments are not working.

A bibliometric analysis of fungal volatile organic compounds

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Fungi release distinctive smells made up of volatile compounds that help them communicate with plants, bacteria, and other organisms. These fungal smell chemicals have grown from being studied mainly in wine fermentation to being explored for helping crops grow better, fighting plant diseases naturally, and creating food flavors without chemicals. This research shows that understanding how fungi use these smell chemicals could lead to more sustainable farming practices and natural alternatives to harmful pesticides.

Harnessing Walnut-Based Zinc Oxide Nanoparticles: A Sustainable Approach to Combat the Disease Complex of Meloidogyne arenaria and Macrophomina phaseolina in Cowpea

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Researchers created tiny particles made from walnut leaves and zinc oxide that can fight harmful plant diseases caused by root-knot nematodes and fungal infections in cowpea plants. When applied to diseased plants, these natural nanoparticles significantly reduced pest populations, improved plant growth and health, and helped plants recover from stress without harming beneficial bacteria in the soil. This green technology offers farmers an environmentally friendly alternative to traditional chemical pesticides.

Screening, Identification, and Fermentation Optimization of the Antagonistic Actinomycete Strain TCS21-117 Against Botrytis cinerea

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Scientists isolated a beneficial bacterium called Streptomyces roietensis from soil that effectively fights gray mold, a serious fungal disease affecting crops worldwide. They identified the strain and optimized growing conditions to maximize production of antifungal compounds, achieving 93% effectiveness against gray mold. This discovery offers a natural, environmentally-friendly alternative to chemical fungicides for protecting agricultural crops, potentially reducing crop losses and environmental pollution.

Identification and antifungal susceptibility patterns of reference yeast strains to novel and conventional agents: a comparative study using CLSI, EUCAST and Sensititre YeastOne methods

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Researchers compared three different laboratory methods for testing how well antifungal drugs work against common yeast infections. They tested 22 different yeast strains including Candida species using CLSI, EUCAST, and Sensititre YeastOne methods. The methods showed strong agreement overall, but some newer antifungal drugs like ibrexafungerp showed more variation between methods. The findings suggest these methods are reliable for guiding treatment decisions, but further standardization is needed for newer drugs.

Essential Oils as an Antifungal Alternative to Control Several Species of Fungi Isolated from Musa paradisiaca: Part III

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This study tested six common essential oils (from oregano, thyme, cinnamon, clove, rosemary, and basil) to see if they could stop five types of fungi that spoil bananas after harvest. Thyme oil worked best, completely stopping fungal growth at the highest concentration tested. Cinnamon and oregano oils also worked well at moderate concentrations. These natural oils could replace synthetic fungicides and help keep bananas fresher longer during storage and transport.

Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action

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Ganoderma is a medicinal mushroom that has been used in traditional medicine for thousands of years and is now being studied for its ability to fight infections. The mushroom contains special compounds like polysaccharides and triterpenoids that can kill harmful bacteria and fungi in multiple ways—by breaking down their cell walls, stopping them from reproducing, and boosting your immune system. Scientists have found that Ganoderma works against many dangerous bacteria including antibiotic-resistant strains, and it may offer a natural alternative to conventional antibiotics as antibiotic resistance becomes a major global health problem.

Clinical aspects and recent advances in fungal diseases impacting human health

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Fungal infections affect over a billion people worldwide and are becoming harder to treat due to growing resistance to antifungal medications. The review discusses major challenges in detecting and treating these infections, including difficulty in diagnosis and limited awareness among healthcare providers. New antifungal drugs are being developed and approved to address these challenges, but a comprehensive approach involving better awareness, improved testing, and responsible medication use is needed.

Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (Tursiops truncatus)

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A bottlenose dolphin at a Japanese aquarium developed a serious fungal infection on its tail fin while suffering from severe digestive problems and weight loss. The infection was caused by two types of fungi that are normally hard to treat because they resist many antifungal medications. Veterinarians successfully treated the dolphin using a combination of two antifungal drugs (voriconazole and terbinafine), surgical removal of dead tissue, and daily wound cleaning with special solutions. The dolphin’s wound eventually healed completely, and this is the first documented successful treatment of these particular fungal infections in bottlenose dolphins.

Antifungal Effects of Pterostilbene on Candida albicans, Candida dubliniensis, and Microcosm Biofilms of Denture Stomatitis

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Pterostilbene, a natural compound found in blueberries and grapes, has been shown to effectively kill Candida fungi that cause denture-related mouth infections. In laboratory tests, it successfully eliminated fungal cells and disrupted harmful biofilms within 8 hours. When tested in a living organism model, pterostilbene proved safe and reduced infection severity, suggesting it could be a promising natural alternative to conventional antifungal medications.

therapeutic action: antifungal activity