Anticancer activity – Page 3

Fungal-fungal cocultivation alters secondary metabolites of marine fungi mediated by reactive oxygen species (ROS)

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Researchers discovered that when two types of ocean fungi grow together, one of them produces a protective chemical called alternariol that can kill bacteria and cancer cells. This happens because the fungi recognize each other as competitors and trigger special stress signals that activate defensive chemical production. Interestingly, fungi from the ocean respond differently than those from land, suggesting they have evolved unique survival strategies for harsh marine environments.

Mycochemistry, antioxidant activity and anticancer potentiality of ethyl acetate extract of Daldinia eschscholtzii against A549 lung cancer cell line

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Researchers studied a wild fungus called Daldinia eschscholtzii to see if it could fight lung cancer. They found that an extract from this fungus contained 28 different beneficial compounds and was effective at killing cancer cells by triggering a process called apoptosis (programmed cell death). The treatment also reduced the cancer cells’ ability to spread, and it appeared safe for normal, healthy cells. Several compounds in the extract showed promise as potential anti-cancer drugs.

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

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Medications we take for health are ending up in our water supplies in significant amounts because standard water treatment plants cannot remove them effectively. These pharmaceutical residues are harming wildlife and aquatic ecosystems, causing problems like population declines in birds, developmental issues in fish, and the spread of antibiotic resistance. Scientists are developing new bioremediation technologies, particularly using fungi and mycoremediation, to better remove these drugs from wastewater before they reach our water bodies.

Ganoderma lucidum inspired silver nanoparticles and its biomedical applications with special reference to drug resistant Escherichia coli isolates from CAUTI

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Researchers created tiny silver particles using a medicinal mushroom called Ganoderma lucidum to fight dangerous bacteria that resist antibiotics and are associated with urinary catheter infections. These nanoparticles were found to effectively kill drug-resistant bacteria, work as antioxidants better than a common antioxidant standard, and showed promise in killing breast cancer cells. This eco-friendly approach offers a natural alternative to conventional antibiotics for treating serious antibiotic-resistant infections.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom species to understand how different growing methods affect its beneficial compounds. They found that growing the mushroom on specific wood substrates (from cinnamon trees) produced much higher levels of therapeutic compounds compared to rice-based cultivation. Using advanced molecular techniques, they identified the genes responsible for producing these medicinal compounds and how they are controlled, providing insights to improve mushroom cultivation for better health benefits.

Microbial-Based Green Synthesis of Silver Nanoparticles: A Comparative Review of Bacteria- and Fungi-Mediated Approaches

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Scientists have developed environmentally friendly ways to create tiny silver particles using bacteria and fungi instead of harsh chemicals. These silver nanoparticles can fight bacteria, help treat cancer, clean contaminated water, and improve food packaging. The review shows that bacteria produce particles quickly but fungi are better for large-scale production and create more stable particles.

Energy Metabolism Enhance Perylenequinone Biosynthesis in Shiraia sp. Slf14 through Promoting Mitochondrial ROS Accumulation

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Scientists studied two similar fungi to understand how one produces more of a beneficial compound called perylenequinones (PQs), which have medical uses against infections and cancer. They discovered that the high-producing strain uses energy more efficiently, which causes tiny structures in the cells called mitochondria to produce reactive molecules (ROS). These reactive molecules trigger the fungus to make more PQs as a protective response. By controlling these processes, researchers can potentially improve the production of this valuable medicine.

Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations

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Scientists are using special fungi called pycnidial fungi to create tiny nanoparticles that could revolutionize medicine and environmental cleanup. These fungi naturally produce chemicals that can turn metal into useful nanoparticles without the toxic processes used in factories. The resulting nanoparticles show promise in fighting bacteria, cancer cells, and cleaning polluted water, offering a safer and more eco-friendly alternative to traditional methods.

Microbial-Based Green Synthesis of Silver Nanoparticles: A Comparative Review of Bacteria- and Fungi-Mediated Approaches

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Scientists are developing environmentally friendly ways to make silver nanoparticles using bacteria and fungi instead of harsh chemicals. These tiny particles show promise in fighting infections, treating cancer, cleaning water, and protecting crops. The review compares how bacteria and fungi each produce these particles and explains how different conditions affect their properties and effectiveness.

Mushrooms Do Produce Flavonoids: Metabolite Profiling and Transcriptome Analysis of Flavonoid Synthesis in the Medicinal Mushroom Sanghuangporus baumii

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Researchers discovered that the medicinal mushroom Sanghuangporus baumii produces 81 different flavonoids, compounds known for their health benefits including antioxidant and anti-cancer properties. Using advanced genetic and chemical analysis, they identified the genes and processes responsible for this flavonoid production in mushrooms, which differs from how plants make these compounds. By increasing the activity of a key gene called PAL, they were able to boost flavonoid production in the mushroom. This discovery opens new possibilities for using mushrooms as biological factories to produce flavonoids for medical and nutritional applications.

therapeutic action: Anticancer activity