anti-tumor – mycolab.ai

Screening of a Fraction with Higher Amyloid β Aggregation Inhibitory Activity from a Library Containing 210 Mushroom Extracts Using a Microliter-Scale High-Throughput Screening System with Quantum Dot Imaging

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Researchers screened 210 mushroom species from Japan to find those that could prevent harmful protein clumping in the brain associated with Alzheimer’s disease. They identified a purified fraction from the mushroom Elfvingia applanata that was more effective than a known anti-Alzheimer’s compound at stopping these protein clumps from forming. The extract also protected nerve cells from damage in laboratory tests. This finding suggests mushrooms could potentially be developed into a functional food to help prevent Alzheimer’s disease.

Functional Components from the Liquid Fermentation of Edible and Medicinal Fungi and Their Food Applications in China

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Mushroom mycelium grown in liquid fermentation produces many beneficial compounds like polysaccharides and proteins that support immune function and may help fight cancer and oxidative stress. These fermented mushroom products can be added to foods, beverages, and health supplements to boost their nutritional value and health benefits. Studies show that fermented mushroom mycelium sometimes contains higher levels of beneficial compounds compared to whole mushroom fruiting bodies, making it a promising ingredient for functional foods and health products.

The Role of Wolfiporia cocos (F. A. Wolf) Ryvarden and Gilb. Polysaccharides in Regulating the Gut Microbiota and Its Health Benefits

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Wolfiporia cocos, a fungus used in traditional Chinese medicine for over 2000 years, contains polysaccharides that act as prebiotics to improve gut health. These polysaccharides promote the growth of beneficial bacteria while inhibiting harmful ones, increase production of healthy metabolites, and strengthen the intestinal barrier. By improving gut microbiota composition, these polysaccharides can help prevent and treat various diseases including obesity, diabetes, and inflammatory conditions.

The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites

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This study examined how growing Ganoderma lucidum (a medicinal mushroom) on the same land for two consecutive years affects the soil and the mushroom’s beneficial compounds. Researchers found that continuous cultivation depleted soil nutrients and reduced enzyme activity, particularly in the top layer of soil. The mushrooms grown in the first year had more beneficial compounds than those grown in the second year, with differences linked to changes in soil quality and microbial activity.

Structural Elucidation, Modification, and Structure-Activity Relationship of Polysaccharides in Chinese Herbs: A Review

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This comprehensive review explains how the structure of plant polysaccharides from Chinese herbs determines their healing properties. The authors discuss various laboratory methods to identify polysaccharide structures and explain how chemical modifications can enhance their beneficial effects like boosting immunity and fighting tumors. The review provides guidance for researchers developing new polysaccharide-based medicines and shows that finding the right molecular size and chemical composition is key to maximizing therapeutic benefits.

Edible mushrooms as emerging biofactories for natural therapeutics and oral biopharmaceutical delivery

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Mushrooms are emerging as natural medicine factories that can be genetically engineered to produce medications taken by mouth. Beyond their traditional use as health foods, scientists are now using advanced genetic techniques to program mushrooms to manufacture therapeutic proteins and vaccines. These engineered mushrooms can naturally package and protect these medications as they pass through the stomach, releasing them safely in the intestines for absorption. This approach offers a sustainable, affordable, and cold-chain-independent alternative to conventional injected medications.

Revitalization of the Endophytic Fungus Acremonium sp. MEP2000 and Its Impact on the Growth and Accumulation of Bioactive Compounds in Inonotus obliquus

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Researchers successfully revived a beneficial fungus called Acremonium sp. MEP2000 that had lost its effectiveness through repeated cultivation by adding birch bark powder and medicinal mushroom powder to its growth medium. When used to treat the medicinal fungus Inonotus obliquus (chaga), this revitalized fungal culture dramatically improved the growth and production of healthy bioactive compounds like polysaccharides and triterpenoids. This breakthrough offers a practical solution for large-scale production of medicinal fungi with enhanced therapeutic potential for treating cancer, diabetes, and inflammatory conditions.

Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

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Mushrooms have been used for health for thousands of years and contain special compounds that help boost the immune system and fight cancer. Scientists have identified several key active ingredients in mushrooms like polysaccharides and proteins that can activate immune cells and reduce tumors. Some mushroom products like lentinan from shiitake mushrooms have already been approved as cancer treatments in Japan. While most evidence comes from lab studies, ongoing research suggests mushroom-based medicines could become important therapeutic options.

Research progress of edible mushroom polysaccharide-metal trace element complexes

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This research reviews how edible mushroom polysaccharides can be combined with essential metals like iron, selenium, and zinc to create health-boosting supplements. These complexes improve how our bodies absorb and use these important minerals, offering benefits like better immune function, antioxidant protection, and potential cancer-fighting properties. Scientists are studying different ways to make these complexes and testing their effectiveness for treating various health conditions.

Comparative Metabolite Profiling Between Cordyceps sinensis and Other Cordyceps by Untargeted UHPLC-MS/MS

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This research compares the chemical compounds found in authentic Cordyceps sinensis with four similar but different Cordyceps species to identify which ones are real. Using advanced laboratory techniques, scientists detected thousands of chemical differences between the species. They found that genuine C. sinensis contains higher levels of specific beneficial compounds like nucleosides and certain fatty acids. These findings help consumers and merchants distinguish authentic Cordyceps from counterfeit products and lower-quality substitutes.

therapeutic action: anti-tumor