anti-inflammatory effects – Page 5

From trial to real life: ten-year impact of a nutraceutical strategy on duodenal polyp burden in familial adenomatous polyposis

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This study followed 56 patients with familial adenomatous polyposis (FAP), a genetic condition causing multiple polyps in the digestive tract, for 10 years. Patients who continuously took Adipol, a supplement made from milk thistle, flaxseed, and oat fiber, had significantly fewer and smaller polyps in the duodenum (part of the small intestine) compared to those who didn’t take it. The supplement appeared safe and well-tolerated over the entire 10-year period, making it a promising preventive strategy for FAP patients.

Comparative transcriptomic insights into the domestication of Pleurotus abieticola for coniferous cultivation

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Researchers studied a special mushroom called Pleurotus abieticola that can grow on coniferous trees like spruce and larch. Usually, mushrooms prefer broadleaf trees, but this species can thrive on conifer wood, which makes up 70% of Chinese forests. By analyzing the mushroom’s genes and growth conditions, scientists found the best ways to cultivate it and discovered it’s rich in protein and beneficial compounds. This breakthrough could help create sustainable mushroom farming using forest resources that were previously underutilized.

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

Association of the use of nonfood prebiotics, probiotics, and synbiotics with total and cause-specific mortality: a prospective cohort study

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This study of over 53,000 American adults found that people taking nonfood supplements containing prebiotics, probiotics, or synbiotics had significantly lower risks of dying from any cause, heart disease, cancer, or other causes compared to those who didn’t take these supplements. The benefits were particularly strong in women and people without high blood pressure. These findings suggest that these supplement types may play an important role in preventing early death.

Efficacy of Lacticaseibacillus rhamnosus probiotic strains in treating chromate induced dermatitis

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This research shows that a beneficial bacteria called Lacticaseibacillus rhamnosus can help treat skin problems caused by chromate exposure, a common hazard for construction workers and factory employees. The bacteria work by reducing toxic chromate to a less harmful form through a special protein called flavin reductase. When tested on mice with chromate-induced skin damage, the probiotic treatment significantly improved skin healing and reduced inflammation. This suggests these beneficial bacteria could offer a safe, natural treatment for occupational skin conditions caused by heavy metal exposure.

Lentinan Alleviated PM2.5 Exposure-Induced Epithelial–Mesenchymal Transition in Pulmonary Epithelial Cells by Inhibiting the GARP/TGF-β/Smad Pathway

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Air pollution particles (PM2.5) can cause serious lung damage by triggering a process called epithelial-mesenchymal transition, where lung cells lose their protective qualities. This study found that a natural compound called lentinan, derived from shiitake mushrooms, can help prevent this harmful process by blocking a protein called GARP. The research suggests that lentinan could be a promising natural treatment for lung diseases caused by air pollution.

Nutrition and Diet in the Prevention and Management of Prostate Cancer in Mexico: A Narrative Review

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This review shows that what men eat significantly affects prostate cancer risk, with certain foods offering strong protection while others increase risk. Traditional Mexican foods like tomatoes, avocados, beans, and whole grains provide excellent protection through antioxidants and healthy fats. Making dietary changes that respect cultural preferences and fit within budgets is more likely to succeed, making food-based prevention a practical strategy for reducing Mexico’s prostate cancer burden.

Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes

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Researchers tested whether magic mushrooms containing psilocybin could be safely used by people with heart failure, especially those dealing with depression. Using laboratory rat heart cells, they found that extracts from Psilocybe cubensis and Panaeolus cyanescens mushrooms actually protected heart cells from damage and reduced harmful inflammation. The mushroom extracts worked similarly to standard heart medications at the tested concentrations, suggesting they may be safe for use under controlled medical supervision.

Psilocybin therapy and anorexia nervosa: a narrative review of safety considerations for researchers and clinicians

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This review examines the safety of psilocybin therapy for treating anorexia nervosa, a serious eating disorder with limited treatment options. The authors analyze how psilocybin’s common side effects (like increased heart rate, nausea, and dizziness) interact with medical complications already present in people with anorexia. Based on early clinical trials, they conclude that psilocybin can be safely used in this population with proper medical screening and monitoring protocols tailored to their specific vulnerabilities.

Neuroprotective Effect of Mixed Mushroom Mycelia Extract on Neurotoxicity and Neuroinflammation via Regulation of ROS-Induced Oxidative Stress in PC12 and BV2 Cells

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A mixture of three medicinal mushrooms (Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus) was tested for its ability to protect nerve cells from damage. The extract successfully reduced cell death in laboratory models of neurodegeneration by reducing harmful molecules called reactive oxygen species and reducing inflammation. These results suggest the mushroom extract could potentially help prevent or slow neurological diseases like Alzheimer’s.

therapeutic action: anti-inflammatory effects