therapeutic action: anti-inflammatory effects

Bioactive Peptides and Other Immunomodulators of Mushroom Origin

Mushrooms contain special compounds called peptides and proteins that can boost your immune system and fight harmful bacteria. These mushroom-derived compounds show promise as natural alternatives to antibiotics, which are becoming less effective due to antibiotic resistance. Researchers are studying how these mushroom compounds could help treat difficult infections, wounds that won’t heal, and cancer, though more testing is needed before they can be used widely as medicines.

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Gut-Brain Axis in Obesity: How Dietary Patterns Influence Psychological Well-Being and Metabolic Health

This review explains how our diet affects both our gut bacteria and our mental health through the gut-brain axis, a communication system between our digestive system and brain. Mediterranean diets rich in fiber and healthy foods support beneficial bacteria and mental well-being, while Western diets high in processed foods harm gut health and increase obesity risk. Emotional eating driven by stress and depression worsens obesity, but targeted dietary interventions with prebiotics, probiotics, and fiber can help restore balance and improve both physical and mental health.

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Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores

Researchers developed an improved method to extract beneficial polysaccharides from Ganoderma leucocontextum (white Ganoderma), a rare mushroom from the Tibetan plateau. The extracted compound GLSP-A1 showed strong anti-inflammatory effects by reducing inflammatory markers and reduced signs of aging in test organisms by decreasing harmful reactive oxygen species and cellular aging pigments. This work suggests the mushroom polysaccharide could potentially be used in dietary supplements to help slow aging.

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Mitigating nickel-induced toxicity: the protective role of native probiotic strains on oxidative stress and inflammatory pathways in mice lung tissues

This study examined how probiotic bacteria can protect lung tissue from damage caused by nickel exposure. Researchers gave mice nickel to cause oxidative stress and inflammation, then treated them with beneficial bacteria from four probiotic strains. The probiotics successfully reduced oxidative stress markers and inflammatory responses in the lung tissue by activating protective genes and deactivating inflammatory genes. This research suggests that probiotics could be a natural way to prevent lung damage from heavy metal exposure.

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Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity

Mushrooms and mushroom stems are emerging as natural feed additives that can significantly improve poultry health, growth, and egg/meat quality while reducing the need for antibiotics. These fungi contain beneficial compounds that boost immune function, reduce harmful bacteria, and protect against cellular damage. By using mushroom byproducts that are typically discarded, farmers can create more sustainable and environmentally friendly poultry production systems while improving overall bird health and productivity.

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Advancing Nutritional Science: Contemporary Perspectives on Diet’s Role in Metabolic Health and Disease Prevention

This research collection shows how what we eat significantly impacts our metabolic health and ability to prevent diseases. Key findings include that eating more vegetables helps prevent metabolic syndrome in older adults, and certain dietary patterns combined with regular exercise reduce disease risk in young adults. The research also highlights the benefits of natural compounds like inulin and royal jelly for managing metabolic disorders, while emphasizing the importance of personalized nutrition approaches for rare conditions.

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Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial

This study tested whether Ganoderma lucidum, a medicinal mushroom used in traditional Asian medicine, could treat denture stomatitis as effectively as the standard treatment clotrimazole. Both treatments reduced pain and improved symptoms equally well over two weeks. The results suggest that Ganoderma lucidum could be a useful alternative for patients who don’t respond well to standard antifungal drugs.

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Dietary live microbe intake and its association with Parkinson’s disease in American adults: an NHANES analysis (1999–2018)

This study found that eating more foods rich in live microbes—like fermented products (yogurt, kimchi) and fresh fruits and vegetables—is associated with lower rates of Parkinson’s disease in American adults. The protective effect was strongest in people without obesity. The live microbes appear to work by maintaining a healthy gut environment, reducing inflammation, and protecting nerve cells from damage. This suggests that regular consumption of microbe-rich foods from nature might be a simple, inexpensive way to help prevent or slow Parkinson’s disease.

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Impact of a Limosilactobacillus fermentum, Quercetin, and Resveratrol Nutraceutical on Fecal Microbiota Composition and Metabolic Activity in Healthy and Hypertensive Subjects

Researchers tested a dietary supplement containing beneficial bacteria and plant compounds on human gut microbiota samples. The supplement successfully modified the composition and activity of gut bacteria in both healthy and high blood pressure patients. The supplement increased production of beneficial acids and modified which bacteria were present in the fermentation samples. These findings suggest this type of supplement could potentially help manage high blood pressure by improving gut health.

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Biological studies of clavine alkaloids targeting CNS receptors

This paper reviews clavine alkaloids, a class of natural compounds from ergot fungi that show promise as psychiatric medications. Unlike well-known psychedelics like LSD, clavine alkaloids may provide therapeutic benefits for anxiety and depression without strong hallucinogenic effects. The authors highlight how these compounds interact with brain receptors in ways that could make them safer and more effective medications for treating mood and neurological disorders.

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