Anti-inflammatory activity – Page 3

Targeted metabolomic and transcriptomic reveal the regulatory network of ultrasound on polyphenol biosynthesis in tender coconut flesh during storage

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Researchers studied how ultrasound treatment affects the polyphenolic compounds (natural antioxidants) in coconut flesh during storage. By analyzing both the chemicals and genes involved, they found that ultrasound helps preserve important polyphenols like catechin and epicatechin by controlling the expression of genes that break them down. This discovery could help extend the shelf life of tender coconut products and maintain their nutritional value.

Synergistic potential and apoptosis induction of Bunium persicum essential oil and its pure components, cuminaldehyde and γ-terpinene, in combination with fluconazole on Candida albicans isolates: in vitro and in silico evaluation

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Researchers studied how Bunium persicum essential oil and two of its active components work together with the antifungal drug fluconazole to fight resistant Candida yeast infections. They found that cuminaldehyde, one of the oil’s main components, was particularly effective when combined with fluconazole and could trigger yeast cell death. These natural compounds could offer a promising new approach to treating fungal infections that have become resistant to standard medications.

Comparison of Ergosterol and Vitamin D2 in Mushrooms Agaricus bisporus and Cordyceps militaris Using Ultraviolet Irradiation Directly on Dry Powder or in Ethanol Suspension

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This study shows that exposing mushroom powder suspended in ethanol to ultraviolet light effectively converts ergosterol (a natural compound in mushrooms) into vitamin D2, which is essential for bone health and immunity. The optimal treatment involves UV-C light exposure for 120 minutes at a specific distance, producing about 15 times more vitamin D2 than direct irradiation of dry mushroom powder. After removing the ethanol, these treated mushrooms could serve as a practical natural source of vitamin D for people with deficiency.

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

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Researchers studied a fungus called Aspergillus ficuum and found it contains compounds with potential medicinal benefits. The fungal extract showed strong antibacterial activity against disease-causing bacteria and reduced inflammation in mice. Additionally, the extract had antioxidant properties that help fight harmful free radicals, with no toxic effects observed, making it a promising candidate for developing new medications.

Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor

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This research explores how medicinal mushrooms, especially a species called Cerrena unicolor, could be used to improve human health through functional foods and dietary supplements. These mushrooms contain natural compounds that fight cancer, bacteria, viruses, and free radicals that damage our cells. Scientists have found that incorporating these mushroom extracts into foods, particularly dairy products, could create powerful health-promoting foods that help with cancer treatment, diabetes management, and wound healing.

Cultivation and mycelium production from spore suspensions of desert truffles: prospective use as inoculum for host plants in arid zones

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Scientists successfully grew two types of desert truffles from Morocco in the laboratory using simple growth materials. By placing spores in potato dextrose agar or malt extract agar, they were able to produce substantial amounts of fungal threads (mycelium) within a week. This achievement is important because these truffles can now be used to help restore desert soils and grow edible mushrooms in arid regions, providing food and income for communities while fighting desertification.

Anticancer Activity of Demethylincisterol A3 and Related Incisterol-Type Fungal Products

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This review examines a group of rare fungal compounds called incisterols, with a focus on demethylincisterol A3 (DM-A3), which has shown promise as an anticancer agent. DM-A3 works through multiple mechanisms including blocking cancer cell signaling pathways, inhibiting specific enzymes, and reducing inflammation. The compound has demonstrated effectiveness against various cancer types in laboratory studies and showed tumor-reducing effects in animal models, suggesting potential for future cancer therapy development.

The Effect of Topical Ketoconazole and Topical Miconazole Nitrate in Modulating the Skin Microbiome and Mycobiome of Patients With Tinea Pedis

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This study examined how two common antifungal creams (ketoconazole and miconazole) affect the complex community of bacteria and fungi living on the skin of people with athlete’s foot. Both treatments effectively reduced the harmful fungus causing the infection and improved symptoms, with ketoconazole working slightly faster. However, the researchers found that while these treatments reduced the disease-causing fungus, the skin’s normal microbial community did not fully recover to a healthy state, particularly in the spaces between the toes.

The polyphasic approach reveals two new species and two new records of Nigrospora (Apiosporaceae, Amphisphaeriales) associated with Aquilaria sinensis from China

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Researchers discovered two previously unknown species of Nigrospora fungi (N. guangxiensis and N. pubeiensis) living inside agarwood tree leaves in southern China. These fungi, along with two other known species, were identified using a combination of microscopic examination and DNA analysis. The findings expand our understanding of fungal diversity in agarwood trees, which are valuable medicinal plants, and may have practical applications for the agarwood production industry.

Scoping Review: The Role of Psychedelics in the Management of Chronic Pain

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This review examines how psychedelic drugs like LSD and psilocybin might help treat chronic pain conditions such as cluster headaches and phantom limb pain. The researchers found nine studies suggesting these substances could reduce pain by affecting serotonin receptors in the brain. While early results are promising, more rigorous clinical trials are needed before these drugs can become standard pain treatments. The authors note that strict legal restrictions on psychedelics currently limit research opportunities.

therapeutic action: Anti-inflammatory activity