therapeutic action: Anthelmintic

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

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This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

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Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research

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Mushrooms and related fungi in the basidiomycete group produce many useful medicines and agricultural chemicals. Scientists have traditionally struggled to study these fungi because they grow slowly and have complex genomes. Recent technological breakthroughs—including faster DNA sequencing and gene-editing tools—are now making it much easier to discover and understand the helpful compounds these fungi produce, potentially leading to new medicines.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

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Scientists have sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research reveals the mushroom’s genetic blueprint, including genes responsible for producing beneficial compounds and adapting to rocky mountain environments. This foundational work aims to enable sustainable cultivation of this rare fungus and development of new medicinal treatments, addressing current conservation threats from over-harvesting.

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Andorran ethnomycology: culinary uses and beyond

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This research documents how people in Andorra traditionally use wild mushrooms for food and medicine. Researchers interviewed 131 older residents and found 50 different types of mushrooms being used, with over 150 local names for them. Most uses were for cooking (97%), with mushrooms being dried, pickled, or frozen. The study identified several mushrooms that might be valuable for future nutritional research and product development.

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Isolation, Identification, Biological Characterization, and Pathogenicity of Entomopathogenic Fungus from the Larvae of the Evergestis extimalis (Scopoli) (Lepidoptera: Pyralidae)

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Scientists discovered a fungus called Mucor hiemalis that naturally infects and kills a harmful rapeseed pest known as Evergestis extimalis. They identified the fungus, found the best conditions for growing it in the lab, and tested how well it kills the pest larvae at different life stages. The results show this fungus could be used as a natural, environment-friendly alternative to chemical pesticides for protecting rapeseed crops.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

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Researchers sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in Chinese traditional medicine for treating parasites and digestive issues. The study reveals the mushroom’s genetic makeup, including 15,847 genes and over 3 million methylation marks that may control gene expression. They identified 67 gene clusters that could produce medicinal compounds and 521 enzymes for breaking down organic matter. This genetic blueprint will help scientists understand how to cultivate this threatened species sustainably and develop its health benefits.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

mycolabadmin

Scientists have sequenced the complete genetic code of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research revealed how this mushroom produces beneficial compounds and how its genes are regulated through a process called methylation. This information could help develop better ways to cultivate this increasingly rare mushroom sustainably rather than harvesting it from the wild, making it available for future medical research and treatment.

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