therapeutic action: β-1

Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis

mycolabadmin

Researchers used heavy-ion radiation to create improved strains of a fungus that produces a precursor to micafungin, an important antifungal drug. The improved strains produced over 3.5 times more of the desired compound than the original strain. By analyzing the genetic changes in these improved strains, the scientists identified which genes were most important for boosting production, helping guide future improvements in manufacturing this life-saving medicine.

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Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis

mycolabadmin

Scientists successfully improved the production of a key ingredient for the antifungal drug micafungin by using heavy-ion radiation to create improved strains of a fungus called Coleophoma empetri. The best mutant strain produced over 250% more of the desired compound than the original strain. By analyzing the genetic changes in these improved strains, researchers identified specific genes related to fungal structure and metabolism that contribute to higher production, providing insights for future improvements to the manufacturing process.

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The in vitro Activity of Echinocandins Against Clinical Trichophyton rubrum Isolates and Review of the Susceptibility of T. rubrum to Echinocandins Worldwide

mycolabadmin

Researchers tested how well three antifungal drugs (micafungin, anidulafungin, and caspofungin) work against a common fungus that causes skin infections. They found that two of these drugs were more effective than the third, suggesting they could be helpful alternatives when standard treatments fail due to drug-resistant fungal strains. The study also reviewed similar research worldwide and found consistent results across different testing methods.

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