α-glucosidase inhibition

Hypoglycemic Properties of Leccinum scabrum Extracts—An In Vitro Study on α-Glucosidase and α-Amylase Inhibition and Metabolic Profile Determination

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Researchers tested birch bolete mushrooms (Leccinum scabrum) for diabetes-fighting properties. They found that extracts from this edible mushroom were exceptionally effective at blocking enzymes that break down carbohydrates, potentially helping control blood sugar levels. The study identified key beneficial compounds including healthy fats and plant alkaloids, suggesting the mushroom could become a functional food or dietary supplement for managing type-2 diabetes.

Extraction, Characterization, Biological Properties, and X-Ray Fluorescence Analysis of Functional Polysaccharides Derived from Limnospira platensis

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Spirulina (Limnospira platensis) is a nutrient-dense microalga that contains beneficial polysaccharides with multiple health benefits. Researchers extracted and analyzed these polysaccharides, finding they have strong antioxidant properties and can help regulate blood sugar levels by inhibiting α-glucosidase enzymes. These compounds also support beneficial gut bacteria growth, making spirulina a promising natural ingredient for functional foods and health supplements.

Insights into the Mechanisms and Functional Effects of Insoluble Dietary Fiber Modification: A Review

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Insoluble dietary fiber is important for digestive health but its rigid structure limits its usefulness in processed foods and medicine. Scientists can modify this fiber using various techniques like heating, pressure, enzymes, and chemicals to make it more effective. When combined properly, these modification strategies can dramatically improve dietary fiber’s ability to lower cholesterol, control blood sugar, and promote beneficial gut bacteria, making it valuable for functional foods and health applications.

From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from Ganoderma species

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This review examines special compounds called meroterpenoids found in Ganoderma mushrooms (commonly known as Reishi). Scientists have identified over 350 of these compounds from 14 different Ganoderma species. These compounds show promise for treating various health conditions including cancer, kidney disease, diabetes, and inflammatory disorders. The researchers also propose how these compounds are made inside the mushroom, which could help scientists produce them more efficiently for medical use.

New bioactive secondary metabolites from fungi: 2024

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Scientists discovered 907 new compounds from fungi in 2024, with most being terpenoids and polyketides that show promise as medicines. These fungal compounds demonstrate strong activity against bacteria, fungi, and inflammation, with some showing potential against cancer and diabetes. The research uses advanced techniques like genome mining and metabolomics to find these compounds more efficiently. This accelerating discovery rate suggests fungi could be a major source for developing new drugs to treat various diseases.

Effects of Rhizopus oligosporus-Mediated Solid-State Fermentation on the Protein Profile and α-Glucosidase Inhibitory Activity of Selenium-Biofortified Soybean Tempeh

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Researchers used a fungus called Rhizopus oligosporus to make selenium-enriched tempeh, a traditional soybean food. The selenium-enriched tempeh had better protein breakdown, higher amino acid levels, and was better at controlling blood sugar than regular tempeh. This research suggests that selenium-biofortified tempeh could be a healthy functional food for people looking to manage blood sugar levels naturally.

Characterizing flavor determinants and α-glucosidase inhibitory components in ancient tea plants and ‘Qiancha 1’ white teas

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Researchers compared white teas made from ancient tea plants (over 100 years old) with modern cultivated tea varieties. The ancient teas had stronger floral aromas and more bitter taste due to higher levels of beneficial compounds. These compounds, particularly trans-β-ionone and β-damascenone, may help regulate blood sugar levels, making ancient tea plants valuable for both flavor and potential health benefits.

Mass Spectrometry-Based Untargeted Metabolomics and α-Glucosidase Inhibitory Activity of Lingzhi (Ganoderma lingzhi) During the Developmental Stages

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Scientists studied how the medicinal mushroom Lingzhi changes chemically as it grows from mycelium through various stages to mature fruiting bodies. They found that the mushroom contains many beneficial compounds, including special molecules called triterpenoids, that help block α-glucosidase, an enzyme involved in blood sugar control. Interestingly, the immature mushroom stage showed the strongest anti-diabetic activity, suggesting farmers should harvest at specific times depending on desired health benefits rather than always waiting for full maturity.

Effects of Rhizopus oligosporus-Mediated Solid-State Fermentation on the Protein Profile and α-Glucosidase Inhibitory Activity of Selenium-Biofortified Soybean Tempeh

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Researchers developed a special tempeh (traditional soybean food) enriched with selenium using a fungus called Rhizopus oligosporus. The selenium-enriched tempeh had improved protein quality with more amino acids and demonstrated strong ability to slow down sugar absorption in the digestive system, similar to diabetes medications. This makes selenium-biofortified tempeh a promising natural functional food for managing blood sugar levels while providing essential selenium nutrients that many people lack.

A New Species and Five New Records of Talaromyces (Eurotiales, Aspergillaceae) Belonging to Section Talaromyces in Korea

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Researchers surveying fungal diversity in Korea discovered one new species of Talaromyces fungus and confirmed five additional species previously unknown to the country. These fungi were isolated from soil, freshwater, and indoor air samples and identified using genetic analysis and visual characteristics. Many species in this fungal genus produce valuable compounds with potential medical and agricultural applications, making them important for biotechnology research.

therapeutic action: α-glucosidase inhibition