Fungal Species:  Wolfiporia extensa

The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

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Scientists have sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research reveals the mushroom’s genetic blueprint, including genes responsible for producing beneficial compounds and adapting to rocky mountain environments. This foundational work aims to enable sustainable cultivation of this rare fungus and development of new medicinal treatments, addressing current conservation threats from over-harvesting.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

mycolabadmin

Researchers sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in Chinese traditional medicine for treating parasites and digestive issues. The study reveals the mushroom’s genetic makeup, including 15,847 genes and over 3 million methylation marks that may control gene expression. They identified 67 gene clusters that could produce medicinal compounds and 521 enzymes for breaking down organic matter. This genetic blueprint will help scientists understand how to cultivate this threatened species sustainably and develop its health benefits.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

mycolabadmin

Scientists have sequenced the complete genetic code of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research revealed how this mushroom produces beneficial compounds and how its genes are regulated through a process called methylation. This information could help develop better ways to cultivate this increasingly rare mushroom sustainably rather than harvesting it from the wild, making it available for future medical research and treatment.

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Genome Editing in the Edible Fungus Poria cocos Using CRISPR-Cas9 System Integrating Genome-wide Off-target Prediction and Detection

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This research developed a new genetic engineering tool for modifying the DNA of Poria cocos, an important medicinal mushroom. This breakthrough allows scientists to precisely edit genes in this fungus for the first time, which could lead to improved cultivation and medicinal properties. Impact on everyday life: – Could lead to more effective and affordable medicinal mushroom products – May help develop improved strains with enhanced health benefits – Could increase production efficiency and availability of this traditional medicine – May enable development of new therapeutic applications – Could help preserve and improve this valuable medicinal resource

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