Fungal Species:  Wistar rats

Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats

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This research investigated how an extract from the medicinal mushroom Agaricus brasiliensis could help treat nerve pain caused by diabetes. The study found that this mushroom extract effectively reduced pain and inflammation while helping control blood sugar in diabetic rats. Impact on everyday life: • Could provide a natural alternative for managing diabetic nerve pain • May help reduce reliance on conventional pain medications with side effects • Demonstrates potential of mushrooms as therapeutic agents • Could improve quality of life for diabetes patients • Suggests new directions for developing natural pain treatments

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Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats

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This research investigated how an extract from the medicinal mushroom Agaricus brasiliensis could help treat newborn jaundice, a common condition affecting most newborns. The study found that the mushroom extract safely reduced elevated bilirubin levels in baby rats without causing liver damage, suggesting it could be a natural alternative to current treatments. Impacts on everyday life: • Provides a potential natural treatment option for newborn jaundice • Offers an alternative for regions without access to conventional phototherapy • Demonstrates a safer treatment method without side effects • Could reduce hospital stays and treatment costs for families • Shows promise for developing new infant care products

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Vanadium-Enriched Cordyceps Sinensis: A Contemporary Treatment Approach to Both Diabetes and Depression in Rats

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This research explored how a special combination of medicinal mushroom (Cordyceps sinensis) enriched with vanadium could help treat both diabetes and depression simultaneously. The study found that this combination effectively lowered blood sugar levels while also reducing depressive symptoms in laboratory rats. This is significant because diabetes and depression often occur together and make each other worse. Impacts on everyday life: • Offers potential new treatment option for people suffering from both diabetes and depression • Demonstrates how natural medicines can be enhanced with minerals for better therapeutic effects • Shows promise for reducing the need for multiple medications by treating two conditions with one approach • Provides evidence for the benefits of traditional medicine when combined with modern scientific methods • Could lead to more cost-effective treatments for patients dealing with both conditions

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An Endophytic Schizophyllum commune Fr. Exhibits In-vitro and In-vivo Antidiabetic Activity in Streptozotocin Induced Diabetic Rats

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This research discovered that a fungus living inside plants (called Schizophyllum commune) could help treat diabetes. The scientists found that extracts from this fungus effectively lowered blood sugar levels and improved various health markers in diabetic rats. This is significant because it offers a potential natural alternative for diabetes treatment. Impacts on everyday life: • Provides a possible new natural treatment option for diabetes patients • Could lead to development of medications with fewer side effects than current diabetes drugs • Demonstrates the value of studying fungi that live in plants for medical purposes • May help reduce healthcare costs if developed into affordable treatments • Shows promise for managing multiple diabetes-related health complications simultaneously

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Mechanism of Action of Natural Compounds in Peripheral Multiorgan Dysfunction and Hippocampal Neuroinflammation Induced by Sepsis

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This research investigated how the medicinal mushroom Coriolus versicolor could help prevent brain damage and cognitive decline caused by severe infections (sepsis). The study found that this natural compound could both reduce immediate infection severity and prevent long-term brain inflammation and dysfunction. Impacts on everyday life: • Offers a potential natural treatment option for preventing cognitive decline after severe infections • Demonstrates how traditional medicinal mushrooms might help protect brain health • Provides new understanding of how infections can lead to long-term brain problems • Suggests possible preventive strategies for reducing dementia risk after serious illness • Shows promise for developing new therapies using natural compounds

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