This research investigated how a medicinal mushroom called Antrodia cinnamomea could help protect against kidney disease in young subjects. The study found that this mushroom extract helped improve kidney function and lower blood pressure by promoting healthy gut bacteria and regulating important biological systems. This has important implications for treating chronic kidney disease, especially in children. Impacts on everyday life: • Offers a potential natural supplement option for supporting kidney health • Demonstrates how traditional medicinal mushrooms can be scientifically validated for modern medical use • Shows promise for managing high blood pressure through natural means • Highlights the importance of gut health in overall wellbeing • Suggests new dietary approaches for preventing kidney disease progression