This research investigated how the medicinal mushroom Ganoderma lingzhi defends itself against infection by a harmful mold pathogen at the molecular level. The study revealed specific genes and biological pathways that are activated or suppressed during infection, providing valuable insights for developing more resistant mushroom strains. Impacts on everyday life: – Helps develop better disease-resistant medicinal mushrooms for healthcare products – Could lead to improved cultivation methods for mushroom farmers – May reduce the need for chemical fungicides in mushroom production – Contributes to more sustainable and efficient production of natural medicines – Could help lower costs of medicinal mushroom products for consumers