This research investigated how an extract from the medicinal mushroom Taiwanofungus salmoneus could enhance the effectiveness of chemotherapy drugs in treating liver cancer. When combined with the chemotherapy drug cisplatin, the mushroom extract showed promising results in killing cancer cells more effectively than either treatment alone. Impacts on everyday life: • Offers potential for more effective liver cancer treatments with fewer side effects • Demonstrates the value of combining natural medicines with conventional treatments • Shows promise for developing new cancer therapies using medicinal mushrooms • Could lead to more affordable cancer treatment options • Highlights the importance of natural product research in modern medicine