Fungal Species: Strobilurus tenacellus

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

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This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

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Benzothiazole—An Antifungal Compound Derived from Medicinal Mushroom Ganoderma lucidum against Mango Anthracnose Pathogen Colletotrichum gloeosporioides

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Scientists discovered that a chemical called benzothiazole found in the medicinal mushroom Ganoderma lucidum can effectively kill the fungus that causes mango anthracnose, a major disease affecting mango crops. The research showed that this natural compound completely stops fungal growth at very low concentrations (50 ppm) and prevents spore germination. This discovery offers a promising eco-friendly alternative to synthetic fungicides that can cause environmental pollution and drug resistance.

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Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research

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Mushrooms and related fungi in the basidiomycete group produce many useful medicines and agricultural chemicals. Scientists have traditionally struggled to study these fungi because they grow slowly and have complex genomes. Recent technological breakthroughs—including faster DNA sequencing and gene-editing tools—are now making it much easier to discover and understand the helpful compounds these fungi produce, potentially leading to new medicines.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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Cacao farmers have struggled to control witches’ broom disease, a fungal infection caused by Moniliophthora perniciosa, because the fungus survives even high doses of strobilurin fungicides. This study reveals how the fungus adapts to the fungicide by switching its metabolism to use alternative energy sources, activating detoxification systems, and using an alternative respiratory pathway. Researchers also discovered that prolonged fungicide exposure can create even more resistant mutants with mutations in genes that control fungal growth and gene expression.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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This research reveals how a fungus that causes disease in cacao plants survives treatment with strobilurin fungicides, which are commonly used in agriculture. Scientists discovered that the fungus adapts by reorganizing its metabolism to compensate for the drug’s effects, activating detoxification systems, and in some cases, developing genetic mutations that enhance resistance. Understanding these survival mechanisms could help develop better strategies to control this economically important crop disease.

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