Fungal Species:  Sprague Dawley rats

Evaluation of the Toxicological Safety of Erinacine A-Enriched Hericium erinaceus in a 28-Day Oral Feeding Study in Sprague-Dawley Rats

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This research examined the safety of lion’s mane mushroom extract enriched with a compound called erinacine A, which has potential benefits for brain health. The study found that even at high doses, the extract was safe and showed no toxic effects in rats over a 28-day period. This is important for establishing its safety for potential use in supplements and medicines. Impacts on everyday life: • Confirms the safety of lion’s mane mushroom supplements for regular consumption • Supports development of natural treatments for neurological conditions • Provides confidence for people seeking natural alternatives for brain health • Helps establish proper dosing guidelines for supplement manufacturers • Opens possibilities for new therapeutic products using this mushroom extract

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Phytochemical Profiles and Inhibitory Effects of Tiger Milk Mushroom (Lignosus rhinocerus) Extract on Ovalbumin-Induced Airway Inflammation in a Rodent Model of Asthma

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This research investigated how Tiger Milk mushroom, traditionally used in Malaysia, could help treat asthma. The study found that extracts from this mushroom reduced inflammation and other asthma symptoms in laboratory rats. This is significant because it validates traditional knowledge with modern science and could lead to new asthma treatments. Impacts on everyday life: • Provides scientific evidence for a natural alternative to conventional asthma medications • Validates traditional medicine practices that have been used for generations • Could lead to development of new asthma treatments with potentially fewer side effects • Offers hope for asthma sufferers looking for complementary treatment options • Demonstrates the value of investigating traditional medicines using modern scientific methods

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Subchronic Toxicity and Genotoxicity Studies of Hericium erinaceus β-Glucan Extract Preparation

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This research evaluated the safety of Lion’s mane mushroom extract through comprehensive toxicology testing. The studies found no harmful effects even at high doses, supporting its safe use in food and supplements. Impact on everyday life: • Confirms the safety of Lion’s mane mushroom supplements for consumer use • Supports the development of new mushroom-based food products • Provides scientific backing for traditional uses of medicinal mushrooms • Helps establish safe dosage guidelines for supplement manufacturers • Gives consumers confidence in using Lion’s mane products

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Nutrition Profile and Animal-Tested Safety of Morchella esculenta Mycelia Produced by Fermentation in Bioreactors

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This research examined the safety and nutritional value of morel mushroom mycelia grown through fermentation. The study is significant because morel mushrooms are expensive and difficult to collect in nature, so finding a safe way to produce them artificially could make their health benefits more accessible. The research confirmed that the lab-grown mycelia are safe for consumption and nutritionally valuable. Impacts on everyday life: – Provides a safer and more reliable source of nutritious morel mushroom compounds – Could lead to more affordable morel mushroom-based health products – Demonstrates a sustainable alternative to wild mushroom harvesting – Offers a new protein-rich food ingredient option – Creates potential for new functional food products with antioxidant properties

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Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

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This research investigated how an extract from the medicinal mushroom Phellinus linteus could help protect against osteoarthritis. The study found that this natural compound helps reduce joint pain and inflammation while protecting cartilage from damage. This is significant because it offers a potential natural alternative to conventional arthritis medications that often have side effects. Impacts on everyday life: • Could provide a safer, natural option for managing arthritis pain • May help people maintain mobility and quality of life as they age • Offers potential alternative to NSAIDs for those who cannot tolerate them • Could reduce healthcare costs associated with arthritis treatment • Demonstrates the value of traditional Asian medicine in modern healthcare

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