Fungal Species: Shiraia sp. Slf14

Energy Metabolism Enhance Perylenequinone Biosynthesis in Shiraia sp. Slf14 through Promoting Mitochondrial ROS Accumulation

Scientists studied two similar fungi to understand how one produces more of a beneficial compound called perylenequinones (PQs), which have medical uses against infections and cancer. They discovered that the high-producing strain uses energy more efficiently, which causes tiny structures in the cells called mitochondria to produce reactive molecules (ROS). These reactive molecules trigger the fungus to make more PQs as a protective response. By controlling these processes, researchers can potentially improve the production of this valuable medicine.

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