This research examined a desert mushroom called Podaxis pistillaris that has been traditionally used as medicine in various cultures. Scientists identified three compounds (epicorazines) that give the mushroom strong antibacterial properties, validating its traditional use. However, they also discovered these compounds could be toxic to human cells, raising safety concerns about using this mushroom as food or medicine. Impacts on everyday life: • Demonstrates the importance of scientifically validating traditional medicines before use • Highlights potential risks of consuming traditional medicinal mushrooms without proper research • Shows how natural compounds can be both beneficial (antibacterial) and potentially harmful • Emphasizes the need for safety testing of natural products used in traditional medicine • Contributes to our understanding of new potential sources of antibacterial compounds