This research examined how a traditional medicinal mushroom called Amauroderma rugosum can help reduce inflammation and act as an antioxidant. The study found that both wild and cultivated forms of the mushroom effectively reduced inflammation markers and increased anti-inflammatory compounds in cells. This validates its traditional use in Asian medicine. Impacts on everyday life: • Provides scientific evidence supporting traditional medicine practices • Demonstrates potential for developing natural anti-inflammatory treatments • Shows that cultivated mushrooms can be as effective as wild ones • Offers a potential natural alternative to synthetic anti-inflammatory drugs • Suggests new ways to help manage inflammatory conditions naturally