This research explores how certain medicinal mushrooms found in South India can act as powerful antioxidants and potential cancer-fighting agents. The study found that four specific mushroom species – Ganoderma lucidum, Phellinus rimosus, Pleurotus florida, and Pleurotus pulmonaris – contain compounds that can protect cells from damage and potentially fight cancer cells. Impacts on everyday life: • These mushrooms could be developed into natural supplements for boosting immune system health • They might provide safer alternatives or complementary treatments for cancer therapy • The findings support the traditional use of medicinal mushrooms in natural medicine • These mushrooms could be incorporated into functional foods for health benefits • The research validates traditional medicine practices and their potential integration into modern healthcare