This research explores natural and synthetic substances that can affect skin pigmentation, using zebrafish as a test model. The study is particularly relevant for developing treatments for skin conditions involving abnormal pigmentation. Impact on everyday life: – Could lead to safer and more effective skin lightening treatments – May help develop better treatments for conditions like melasma and age spots – Could provide natural alternatives to current synthetic skin whitening products – May lead to improved understanding of skin pigmentation disorders – Could result in new cosmetic products with fewer side effects