This research investigated how an extract from the medicinal mushroom Phellinus linteus could help protect against osteoarthritis. The study found that this natural compound helps reduce joint pain and inflammation while protecting cartilage from damage. This is significant because it offers a potential natural alternative to conventional arthritis medications that often have side effects. Impacts on everyday life: • Could provide a safer, natural option for managing arthritis pain • May help people maintain mobility and quality of life as they age • Offers potential alternative to NSAIDs for those who cannot tolerate them • Could reduce healthcare costs associated with arthritis treatment • Demonstrates the value of traditional Asian medicine in modern healthcare