Fungal Species: Not applicable

The refractory nailbed ulceration caused by Candida parapsilosis after nail extraction

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An 82-year-old woman developed a stubborn ulcer on her toenail bed after having the nail surgically removed to treat an infected nail fold. Testing revealed the ulcer was caused by a yeast called Candida parapsilosis, which typically causes infections after physical trauma or injury to the skin. Treatment with an antifungal medication called fluconazole successfully healed the ulcer over three months. This is the first reported case of this specific type of infection following nail removal and highlights the importance of properly identifying the cause of chronic nail infections.

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Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains

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Researchers discovered that brown locusts in South Africa can carry a dangerous drug-resistant fungus called Candida auris in their digestive systems. This fungus, which causes serious infections in hospitals and is resistant to the antifungal drug fluconazole, may use locusts as a way to spread to humans or other environments. The study suggests that insects could play an important role in how dangerous fungi emerge and spread globally, particularly in warm climates where locusts thrive.

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Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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This study examined fungal infections in HIV-positive patients’ mouths at an Indonesian hospital. Researchers identified which Candida species caused the infections and tested how well common antifungal medications worked against them. They found that while a specific antifungal drug (fluconazole) was effective in most cases, some infections showed resistance, suggesting the need for careful monitoring and personalized treatment approaches.

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Diagnostic Approaches to Invasive Candidiasis: Challenges and New Perspectives

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Invasive candidiasis is a dangerous fungal infection affecting critically ill hospital patients. Current testing methods like blood cultures are slow and unreliable, so doctors are developing faster tests using DNA detection and biomarkers. A combination of new diagnostic tools and prompt treatment with antifungal medications is essential to improve survival rates and reduce complications from this serious infection.

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Clinical, Laboratory, and Biomarker Predictors of 90-Day Mortality in Non-HIV, Non-Transplant Pneumocystis Pneumonia

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This study examined pneumocystis pneumonia in immunocompromised patients who do not have HIV or transplants. Researchers found that older patients with other health conditions were at higher risk of death within 90 days. High levels of fungal markers and low immune cell counts were better predictors of poor outcomes than traditional inflammation markers, suggesting doctors should focus on early identification and personalized treatment approaches.

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Microbe-induced gene silencing of fungal gene confers efficient resistance against Fusarium graminearum in maize

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Scientists developed a new method called microbe-induced gene silencing (MIGS) to protect maize crops from a destructive fungus called Fusarium graminearum, which causes stalk rot. They engineered a beneficial fungus (Trichoderma harzianum) to produce small RNA molecules that target and disable a critical gene in the pathogenic fungus, weakening its ability to infect plants. When maize seedlings were grown with this engineered beneficial fungus, they showed significantly better growth and reduced fungal infection compared to untreated plants. This approach offers an environmentally friendly alternative to chemical pesticides and does not require genetically modifying the crop itself.

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Current taxonomic status of the cultivable and uncultivable Paracoccidioides species

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Researchers have clarified the scientific names and classification of five species of fungus that cause disease in humans and dolphins. Some previously proposed species names were found to be invalid because they didn’t follow proper naming rules. The paper recommends that scientists use updated disease names like paracoccidiodomycosis instead of the older term lobomycosis to maintain consistency in medical terminology.

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