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Endocarditis caused by Scopulariopsis brevicaulis with disseminated emboli and multiple vascular aneurysms: A case report and literature review

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A 61-year-old man with a prosthetic aortic valve developed a rare fungal infection caused by Scopulariopsis brevicaulis, a mold usually associated with nail infections. The infection spread throughout his body, causing multiple strokes and aneurysms that required emergency surgery and treatment with various antifungal medications. This case highlights the serious complications that can occur when this typically harmless fungus invades the heart and demonstrates the challenges doctors face in treating such rare infections, as the fungus was resistant to many common antifungal drugs.

Clinical and Molecular Characterization of Feline Sporotrichosis in the Brazilian Amazon: PCR-Based Identification of Sporothrix brasiliensis

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This research studied a fungal disease called sporotrichosis that affects cats in the Brazilian Amazon and can spread to humans. Most infected cats were young males that roamed freely outdoors and had skin lesions on their faces and paws. Researchers tested different laboratory methods to identify the fungus and found that a specific technique extracted DNA best. They confirmed that Sporothrix brasiliensis was the cause and tested how well common antifungal medications work against it, finding that some drugs work better than others.

Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan

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Candida albicans is a fungus that causes infections in humans. The fungus has developed a clever way to hide from our immune system by covering up a molecule on its surface called β-1,3-glucan that normally triggers immune responses. This study shows that the fungus masks this molecule through a combination of growing and dividing to create new surfaces, and then using enzymes to trim away exposed molecules. The research reveals that a specific cell signaling pathway controlled by lactate (a chemical found in our bodies) activates this masking behavior, helping the fungus evade immune recognition.

Shared Vision for Improving Outcomes for Serious Fungal Diseases: Report of a Patient, Caregiver, and Clinician Summit

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Patients with serious fungal infections face significant challenges including long delays before diagnosis, substantial emotional and financial burden, and lasting effects on quality of life. A summit brought together patients, their caregivers, and fungal disease experts to share experiences and identify priorities for improving care. The group identified needs for better diagnostic tools, new treatments, improved medical education about fungal diseases, and patient support programs to help future patients and their families navigate fungal infections more effectively.

First case of fungemia caused by a rare and pan-echinocandin resistant yeast Sporopachydermia lactativora in China

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A 37-year-old woman with leukemia developed a rare blood infection caused by a yeast called Sporopachydermia lactativora, which had never been documented to cause bloodstream infection in China before. This yeast is naturally resistant to a common class of antifungal drugs called echinocandins, making it particularly challenging to treat. However, the patient responded well to a different antifungal medication called voriconazole and fully recovered. The researchers suggest that this unusual yeast should be monitored in hospitals as it could become a more common infection in vulnerable patients.

Changes in friluftsliv (outdoor recreation) activities among Norwegian adolescents during the SARS-CoV-2 pandemic

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During the COVID-19 pandemic, Norwegian teenagers spent less time in outdoor recreation activities overall compared to before the pandemic. However, when they did engage in outdoor activities, they found them much more important for spending time with friends and family. Outdoor recreation became a critical way for teenagers to maintain social connections when schools, gyms, and other gathering places were closed. This shows how nature and outdoor activities can be valuable for young people’s wellbeing during difficult times.

The small GTPases FoRab5, FoRab7, and FoRab8 regulate vesicle transport to modulate vegetative development and pathogenicity in Fusarium oxysporum f. sp. conglutinans

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Researchers studied three important protein switches (Rab GTPases) in a fungus that causes cabbage wilt disease. By deleting these proteins one at a time, they found that each plays a critical role in fungal growth, spore production, and the ability to infect plants. The findings suggest that targeting these proteins could be a strategy to control the devastating cabbage wilt disease.

Epidemiological Profile of Otomycosis at the Peace Hospital of Ziguinchor (Senegal)

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This study examined fungal ear infections in a hospital in Senegal and found that about 85% of suspected cases were actually caused by fungi. The most common fungi were Aspergillus and Candida species. The research shows that itching was the main symptom associated with fungal ear infections, and that proper diagnosis is important to avoid unnecessary antibiotic use and provide better treatment.

Mechanisms of Talaromyces marneffei induced CNS injury: Synergistic roles of tauopathy, pyroptosis, and microglial inflammation

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A dangerous fungus called Talaromyces marneffei can invade the brain and cause serious damage in people with weakened immune systems. The study shows the fungus harms brain cells through two pathways: direct damage to neurons and indirect damage through activation of brain immune cells that release harmful inflammatory chemicals. Understanding these mechanisms could help develop better treatments for this life-threatening infection.

Past, present and future of antifungals: Advancements in mechanisms of action and resistance

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Fungal infections are a growing global health problem, particularly for people with weakened immune systems, causing millions of deaths annually. Current antifungal medications are limited and increasingly ineffective due to drug-resistant fungi. This special issue explores new treatment strategies including novel drugs, combination therapies, and innovative approaches like nanoparticles and antimicrobial peptides to combat these serious infections.

Fungal Species: None