None – Page 12 – mycolab.ai

Safety and efficacy of the swift microwave device in patients with mild-to-moderate onychomycosis: Protocol of an open-label, randomized, dose-finding pilot study

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This study evaluates a new microwave device (Swift System) as a potential treatment for fungal nail infections (onychomycosis). The device uses microwave energy to heat and eliminate fungal infections directly at the nail site, avoiding the side effects of oral medications. Researchers tested three different treatment schedules in 39 patients over 12 months to find the most effective dosing approach.

Design of a melting curve analysis (MCA) based on multiplex real-time PCR for detection of Aspergillus terreus and Aspergillus fumigatus in cereals and oilseeds samples

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This study developed a fast molecular test using real-time PCR to detect harmful Aspergillus fungi in grains and seeds. Instead of waiting 3-5 days for traditional culture methods, this new test can identify the fungi in just hours by detecting specific DNA patterns. The test was tested on 140 samples of cereals and oilseeds and proved more accurate than traditional methods, making it useful for food safety in markets and processing plants.

Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway

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Scientists extracted a compound called nomilin from yuzu seeds and tested whether it could lighten skin by reducing melanin production. They found that nomilin works by blocking an enzyme called tyrosinase that makes melanin, and it reduces the activity of cell signaling pathways involved in skin darkening. The study shows nomilin could be used as a natural skin-whitening ingredient in cosmetics without the side effects of synthetic alternatives.

Dendritic Cell-Based Therapeutic Immunization Induces Th1/Th17 Responses and Reduces Fungal Burden in Experimental Sporotrichosis

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Researchers developed a vaccine using special immune cells called dendritic cells loaded with proteins from the fungus that causes sporotrichosis. When vaccinated mice were later infected with the fungus, they showed stronger immune responses and had lower levels of the fungus in their bodies. This suggests that dendritic cell-based vaccines could be a promising new treatment approach for sporotrichosis, a serious fungal infection that is difficult to treat with current medicines, especially in people with weakened immune systems.

Identification of Challenging Dermatophyte Species Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

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This study shows that MALDI-TOF mass spectrometry is an effective method for quickly identifying skin fungal infections caused by dermatophytes. By combining commercial reference databases with a custom library created from local isolates, researchers achieved 90.7% accurate identification compared to only 16.1% using the commercial database alone. This improved method could help doctors diagnose and treat fungal skin infections more quickly and accurately in clinical laboratories.

Randomized control trial to study the effectiveness of tablet Fluconazole, capsule Itraconazole and tablet Terbinafine in superficial dermatophytosis

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This study tested three common antifungal medications used to treat fungal skin infections like ringworm. The research involved 180 patients who were randomly given one of three drugs and then checked at 4 and 8 weeks to see if the infection was gone. Itraconazole worked best, clearing infections in about 87% of patients, followed by Fluconazole at 73%, and Terbinafine at 63%.

Inhibitory Effects and Mechanisms of Perilla Essential Oil and Perillaldehyde against Chestnut Pathogen Botryosphaeria dothidea

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Chestnuts often rot during storage due to fungal infection. This study found that oil extracted from perilla leaves, particularly a compound called perillaldehyde, effectively prevents the fungus Botryosphaeria dothidea from growing. The antifungal compounds work by breaking down the protective layers of the fungal cells, causing them to leak and die. When applied to stored chestnuts, this natural oil significantly extends their shelf life without harming human health.

Co-application of dazomet and azoxystrobin reconstructs soil microbial communities and suppresses the violet root rot of Codonopsis tangshen under a continuous cropping system

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Codonopsis tangshen is an important medicinal plant in China, but it suffers from a serious fungal disease called violet root rot when grown repeatedly in the same soil. Researchers found that treating soil with dazomet fumigant followed by azoxystrobin fungicide completely eliminated this disease while dramatically increasing plant yields. The treatment works by reducing the harmful fungus while promoting growth of beneficial soil microbes that naturally suppress disease.

Diversity and Distribution of Fungal Infections in Rwanda: High Risk and Gaps in Knowledge, Policy, and Interventions

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This comprehensive review reveals that Rwanda faces significant challenges from fungal infections affecting humans, crops, and food security, yet has very limited systems to detect, report, or manage these infections. The study found various dangerous fungi causing infections ranging from vaginal candidiasis to serious disseminated infections, as well as crop-destroying soil fungi threatening bean production. The researchers emphasize that Rwanda urgently needs better diagnostic tools, trained healthcare workers, and coordinated public health strategies to combat the growing threat of fungal diseases.

Fungal alkaloids mediate defense against bruchid beetles in field populations of an arborescent ipomoea

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Morning glory trees (Ipomoea murucoides) form beneficial relationships with fungal partners that live inside their tissues and produce toxic compounds called alkaloids. These alkaloids accumulate in the tree’s seeds and protect them from beetle damage. Trees hosting the common fungal partner Ceramothyrium produce more of the protective alkaloid swainsonine and suffer less seed damage than those with a different fungal partner, demonstrating how this natural partnership helps the plant defend its offspring.

Fungal Species: None